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奥氮平与氟哌啶醇治疗谵妄的对照研究 被引量:8

Olanzapine vs Haloperidol for Delirium:A Prospective Randomized Controlled Trial
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摘要 目的比较非典型抗精神病药物奥氮平与传统抗精神病药物氟哌啶醇治疗谵妄的疗效和安全性。方法符合标准的98例谵妄病人随机分为奥氮平组(n=40)、氟哌啶醇组(n=38)和对照组(n=20),用简明精神病评定量表(BPRS)、临床总体印象量表严重程度(CGI-SI)评定疗效,用副反应量表(TESS)和实验室检查评定不良反应和安全性。观察时间为期1周。结果奥氮平组、氟哌啶醇组和对照组的显效率分别为82.5%、78.9%和30%,两治疗组和对照组比较,差异有显著性(P<0.01),两治疗组之间比较差异无显著性(P>0.05)。奥氮平组不良反应总发生率为17.5%,氟哌啶醇组为52.6%,差异有显著性(P<0.01)。结论奥氮平治疗谵妄病人安全有效,疗效与氟哌啶醇无差异,副反应较轻,可替代传统抗精神病药用于谵妄治疗。 Objective To compare the efficacy and safety of atypical antipsychotic agent olanzapine and typical antipsychotic agent haloperidol in the treatment of delirium. Methods Ninety-eight patients with delirium were randomly divided into three groups,i. e groups receiving olanzapine (n = 40), haloperidol (n = 38) for treatment of delirium, and group with only therapy for the diseases causing delirium (n = 20, control). Patients were prospectively observed and treated for a week Their mental and physical status were assessed with Brief Psychiatric Rating Scale (BPRS), Clinical Global Impression Scale (CGI), Treatment Emergent Symptom Scale (TESS)and through laboratory examinations of blood and urine, the function of liver and kidney and ECG. Results The effective rate in olanzapine group, haloperidol group and control group was 82. 5%, 78. 9% and 30% respectively, with significant difference between two treatment groups and control group (P〈0. 01) and no significant difference between the treatment groups (P〉0. 05). The total incidence rate of side effects in haloperidol group was significantly higher than that in olanzapine group (P〈0. 01). Conclusion Olanzapine and haloperidol have similar effects on delirium. However, olanzapine has fewer side effects. Olanzapine may be a useful alternative agent to classical antipsychotics in treatment of delirium.
出处 《华南国防医学杂志》 CAS 2008年第6期1-3,共3页 Military Medical Journal of South China
基金 国家自然科学基金项目(30670758)
关键词 谵妄 奥氮平 氟哌啶醇 Delirium Olanzapine Haloperidol
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参考文献9

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