摘要
目的分析乙酸纤维素中有机挥发性杂质。方法采用水溶液顶空进样气相色谱法,用Agilent DB-5柱(30m×0.53mm,1μm),火焰离子化检测器(FID),按外标法进行定量。结果顶空气相色谱法对待测溶剂具有良好的分离度,在所考察的质量浓度范围内,各溶剂的峰面积与质量浓度线性关系良好(n=5)。结论顶空气相色谱法简单、准确、灵敏,可用于乙酸纤维素中有机挥发杂质的检测。
Objective To establish a method for the determination of organic volatile impurities in cellulose acetate by headspace gas chro- matography（GC）. Methods The sample was dissolved in water. The Agilent DB-5 capillary column and FID detector were used. The level of organic volatile impurities was quantitatively determined by headspaee GC and external method. Results The peaks of impurities were separated well. The good linear correlations were obtained during the detection （n =5）. Conclusion The method is proved to be sensitive and accurate, t can be applicable in the detection of organic volatile impurities in cellulose acetate.
出处
《中国药业》
CAS
2008年第24期30-31,共2页
China Pharmaceuticals
