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E1B缺失腺病毒在肿瘤治疗中的进展 被引量：1

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摘要 近年来具有复制能力的病毒用于治疗恶性肿瘤的研究进展相当迅速,其中敲除了E1B-55KDa的条件复制性溶瘤腺病毒(ONYX-015)治疗肿瘤的研究尤为深入。虽然目前对于ONYX-015选择性溶瘤的机制仍有争论,但多个临床前动物实验及Ⅰ、Ⅱ期临床实验已经证实ONYX-015对于治疗多种恶性肿瘤有一定疗效,不良反应少,安全性及耐受性均较好。该文旨在对近年来ONYX-015在肿瘤治疗中的进展作一综述。
作者 魏小雷 邹晓平
机构地区 南京医科大学鼓楼临床医学院
出处 《江苏医药》 CAS CSCD 北大核心 2008年第12期1274-1276,共3页 Jiangsu Medical Journal
关键词 E1B缺失腺病毒 肿瘤治疗 ONYX-015 溶瘤腺病毒 Ⅱ期临床实验 恶性肿瘤 复制能力 动物实验
分类号 R73-362 [医药卫生—肿瘤] R730.5 [医药卫生—肿瘤]
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参考文献14

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江苏医药
2008年 第12期

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