摘要
【目的】观察补肾益气活血方参乌冠心颗粒治疗冠心病心绞痛中医辨证属肾虚血瘀证的临床疗效。【方法】将90例冠心病心绞痛患者,依据随机双盲双模拟的原则分为治疗组60例和对照组30例,两组均给予西医常规治疗,治疗组在此基础上加服参乌冠心颗粒,对照组在此基础上加服地奥心血康。治疗4周后进行心绞痛疗效、心电图疗效和主要症状疗效评定,并对血脂各项指标进行治疗前后比较。【结果】治疗组患者心绞痛疗效总有效率、心电图疗效总有效率分别为91.7%、85.0%,优于对照组的73.3%、66.7%(P<0.01)。两组治疗后血清总胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白的水平均有改善(与治疗前比较,P<0.05或P<0.01),其中治疗组在改善总胆固醇、甘油三酯、高密度脂蛋白方面明显优于对照组(P<0.05或P<0.01或P<0.001)。在缓解腰膝酸软、耳鸣健忘、少寐多梦等症状方面,治疗组优于对照组(P<0.01),并能改善胸痛、胸闷等症状。【结论】参乌冠心颗粒治疗冠心病心绞痛肾虚血瘀证疗效确切,早期运用补肾益气活血方治疗冠心病心绞痛,可抑制病情发展。
Objective To observe the therapeutic effect of Shen Wu Guanxin Granules （ SWGG）, a prescription with the actions of tonifying kidney, strengthening Qi and activating blood, for angina pectoris （AP） due to coronary heart disease （CHD） with kidney deficiency and blood stasis. Methods Ninety patients with AP due to CHD with kidney deficiency and blood stasis were randomized into two groups according to the double-blind and double-dummy principles. The two groups received routine western medicine, and the treatment group （N = 60） received SWGG and the control group （N = 30） received Di＇ao Xinxuekang Capsules additionally. The treatment lasted 4 weeks. After treatment, the therapeutic effect on AP and electrocardiogram （ECG） was evaluated, and the changes of main symptoms as well as the laboratory parameters were observed before and after treatment. Results In the treatment group, the total therapeutic effect on AP and ECG was 91.7% and 85.0% respectively, higher than 73.3% and 66.7% in the control group （P 〈 0. 01 ）. The serum levels of total cholesterol （ TC）, triglyceride （TG）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL） were improved in the two groups after treatment （P 〈0.05 or P 〈0.01 compared with those before treatment）, and the treatment group had better effect on TC, TG and HDL than the control group （P 〈0. 05, P 〈0. 01 or P 〈0. 001 ）. The symptoms of sore waist and knee joint, tinnitus and amnesia were relieved in the treatment group （P 〈 0.01 compared with the control group）, so did the chest pain and chest distress. Conclusion SWGG has certain therapeutic effect for AP due to CHD with kidney deficiency and blood stasis. Early application of SWGG can block the progress of AP due to CHD.
出处
《广州中医药大学学报》
CAS
2008年第5期391-394,共4页
Journal of Guangzhou University of Traditional Chinese Medicine
