摘要
目的:分析局部抗青光眼药物对眼表的毒性作用。方法:回顾性分析12例青光眼患者局部抗青光眼药物治疗诱导的局部不良反应。结果:12例青光眼患者均使用2种以上局部抗青光眼药物≥0.5a,出现眼部刺激症状,眼球充血、角膜点状染色,给予至少1种抗生素、1种抗病毒眼药水,和抗过敏眼药点眼,病情加重。停用所有眼局部用药后,眼部表现缓解、消失。结论:长期抗青光眼治疗,出现眼表疾病,或眼表疾病控制不满意、加重时均应考虑药物毒性的发生;局部抗青光眼药物导致的结膜和角膜改变是可逆的。
AIM： To evaluate the toxic effects of antiglaucoma eye drops on ocular surface. METHODS： The adverse effects on ocular induced by antiglaucoma eye drops were retrospectively analyzed. RESULTS： Twelve cases were treated with 2 or more antiglaucoma drugs for at least half a year, presented eye irritation symptoms, conjunctival redness and superficial punctuate keratitis. The eye symptoms and objective signs of conjunctival and corneal damages aggravated after treated with antibiotic, virus and anti-anaphylaxis drops, but after stopped all eye drops, those presentations mentioned above relieved or disappeared. CONCLUSION ： Drug toxicity should be considered after long term use of antiglaucoma drops. The adverse effects on ocular induced by antiglaucoma eye drops are reversible.
出处
《国际眼科杂志》
CAS
2008年第12期2549-2550,共2页
International Eye Science
