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胚胎基因组的形成和激活 被引量：5

Reconstruction and activation of embryonic genome
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摘要 早期胚胎缺乏转录活性,由母源性的转录产物所调控,随着胚胎的发育,胚胎的基因组逐渐形成并被激活。胚胎基因组的形成和激活在早期胚胎的发育中起关键作用,主要包括胚胎细胞核的形成和胚胎细胞质由转录抑制状态向激活状态转变。本文对胚胎基因组的形成和激活的基本特点和分子机制进行综述。 Reconstruction and activation of the embryonic genome after fertilization is a complex process. Precise control of embryonic genome activation （EGA） is essential for normal embryogenesis. Genome activation occurs in a stepwise manner. Changes in nuclear structure, ehromatin structure, and cytoplasmic content regulate the period of EGA. Successful activation of gene transcription regulatory mechanisms play key roles in preimplantation development.
作者 姚元庆 张新艳
机构地区 解放军总医院妇产科
出处 《生殖医学杂志》 CAS 2008年第6期499-502,共4页 Journal of Reproductive Medicine
关键词 胚胎基因组激活 早期胚胎发育 基因表达 Embryonic genome activation Early embryonic development Gene expression
分类号 Q132.7 [生物学—普通生物学]
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同被引文献44

  • 1孙海翔,胡娅莉,王玢,陈骞,张宁媛,陈华,王俊霞.体外受精移植胚胎数对临床妊娠率的影响[J].中国实用妇科与产科杂志,2005,21(12):730-732. 被引量：8
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生殖医学杂志
2008年 第6期

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