摘要
目的探讨可吸收聚消旋乳酸棒（poty-D，L-lactide acid，PDLLA）垂直骺板植入对幼兔股骨远端骺板生长的影响。方法采用封闭群系5周龄日本大白兔24只，随机分为两组：1．0min、2．0mm组，每组12只。在幼兔右侧股骨远端跨骺板中心分别垂直植入直径为1．0mm、2．0mm的PDLLA棒；左侧作为对照，只作膝关节切开，不钻孔，不植入。电脑计算骺板损伤面积，术后6、12、24周处死动物。通过测量双侧股骨长度、双侧膝关节外翻角、组织病理学、骨骺磨片和透射电镜等方法观察PDLLA棒对骺板生长的影响。结果1．0mm、2．0mm的PDLLA棒垂直植入所造成的骺板损伤分别占骺板面积的（1．39±0．09）％、（3．33±0．92）％；术后6、12、24周各组内实验侧和对照侧相比，双侧股骨长度、外翻畸形无明显差异（P〉0．05）。结论可吸收聚消旋乳酸棒垂直骺板植入不会对兔骺板生长造成不良的影响。
Objective To investigate the influence of absorbable poly-D, L-lactide acid （ PDLLA） rods on the development of epiphyseal plate after perpendicularly implanted into the distal femoral epiphysis in skeletally immature Japanese white rabbits. Methods Twenty-four Japanese white rabbits with the age of 5 week old were randomly divided into 2 groups according to the diameter of rods： 1.0 mm PDLLA rod group and 2. 0 mm PDLLA rod group. The absorbable PDLLA rods were perpendicularly placed into a drill hole with an equal size in the intercondylar portion of the right femur, crossing the central portion of epiphyseal plates. A similar arthrotomy was performed in the left knee, which served as a negative control, with no drilling or implanting. The area of injured epiphyseal plates was calculated by computer. After the animals were sacrificed at 6, 12 and 24 weeks postopera- tively, gross observation, radiographic measurement of both knee joint valgus angles, histology sections, ground section and scanning microscopy were performed to evaluate the development of epiphys- eal plates. Results The proportions of injured area caused by drill holes in 1.0 mm group were （1.39 ± 0. 09） % and （3. 33 ± 0. 92） % in 2. 0 mm group. At 6, 12 and 24 weeks after operations, there was no significant difference in femur lengths and valgus angles between two sides in each group. Conclusions The PDLLA rod of small diameter perpendicularly implanted into the distal femoral epiphysis causes no disturbance to the development of epiphyseal plates.
出处
《中华小儿外科杂志》
CSCD
北大核心
2008年第12期757-761,共5页
Chinese Journal of Pediatric Surgery
关键词
骺板
骨折固定术
模型
动物
Epiphyseal plate
Fracture fixation, internal
Models, animal
