摘要
检测490例北京西南地区中、晚期妊娠组(238例)和非妊娠妇女的甲状腺激素及自身抗体水平。用微粒子捕获化学发光免疫分析技术(CMIA)测定血清TT4、TT3、FT4、FT3、TSH、TGAb、TPOAb水平及血糖、总胆固醇、甘油三酯水平。结果表明,妊娠组的FT3、FT4水平低于非妊娠组,TT3、TT4水平高于非妊娠组,均有显著性差异(P<0.01);两组TSH水平无显著性差异(P>0.05);妊娠组TGAb阳性率为13.1%,TPOAb阳性率11.0%;非妊娠组TGAb阳性率为13.5%、TPOAb阳性率9.5%,两组阳性率无显著性差异(P>0.05),但均高于文献报导。妊娠组TPOAb与TSH呈显著正相关(P<0.01),血糖低于非妊娠组,血总胆固醇和甘油三酯水平高于非妊娠组,并均有显著性差异(P<0.01)。在10例FT4水平降低的妊娠妇女中,其中有5例合并自身抗体增高;在9例TSH水平异常的妊娠妇女中,1例合并自身抗体增高。在妊娠期间甲状腺功能减退的发生率高于非妊娠期,并且T3/T4增高,表明在中、后期妊娠妇女有碘缺乏的迹象。
To investigate thyroid function of 490 women in Beijing southwest area, the serum samples of 238 pregnant women and 252 non - pregnant women were collected and separated into pregnant group and non - pregnant group. The serum levels of TT4, TT3, FT4, FT3, TSH, TPOAb and TGAb, serum glucose and lipid levels of these people were measured by CMIA. The results showed that serum FT3 and FT4 levels of pregnant group were lower than that of non - pregnant group, and the serum TT3 and TT4 levels were higher than that of non -pregnant group. There were significant differences between two groups in these four assays （P 〈0.05）. There was no significant difference in TSH levels between two groups. The positiverates of TGAb and TPOAb were 13.1% and 11.0% in pregnant group, 13.5% and 9.5% in non-pregnant group respectively, but there was no significant differences between two groups. The serum glucose level of pregnant group was lower than that of non - pregnant group ; the serum liquid levels of pregnant group were higher than that of non -pregnant group; and there were significant differences between two groups （P 〈0.01 ）. The serum thyroid＇ s antibodies levels were increased in 5 of 10 eases with low FT4 levels and 1 of 9 abnormal TSH cases. The thyroid function, glucose level and lipid levels were obviously changed in pregnant peiod. There was an increased risk of thyroid function decrease in pregnant woman and the increased T3/T4 may indicate the deficiency of iodine in pregnant women.
出处
《标记免疫分析与临床》
CAS
2008年第6期373-375,共3页
Labeled Immunoassays and Clinical Medicine
关键词
甲状腺功能
甲状腺自身抗体
微粒子捕获化学发光免疫分析法
Examination of thyroid function
Autoantibody of thyroid
Chemiluminescent micropar ticleimmunoassay
