摘要
对头孢类药物中间体7-TMCA盐酸盐的合成工艺进行了研究。以1-甲基-5-巯基四氮唑和7-ACA为原料,三氟化硼乙腈配合物为催化剂合成了7-TMCA盐酸盐,反应收率可达91.80%.产物经熔点、IR分析确定了结构,对7-TMCA盐酸盐的HPLC分析方法进行了研究,运用该法分析条件按面积归一法测得合成产物含量为99.33%。
The synthesis technology of 7-TMCA·HCl was studied,which was intermediate of cephalosporins.with 1-methylte-trazole-5-thiol and 7-ACA as the material and acetonitrile-boron trifluoride complex as Catalysts,7-TMCA·HCl was preparated and the yield could reach 91.80%.The product structure was confirmed by melting points and IR spectra.Research on HPLC analysis method for 7-TMCA·HCl,under which,its content was measured to be 99.33% by the area normalization method.
出处
《化工时刊》
CAS
2008年第12期23-25,共3页
Chemical Industry Times
