摘要
目的了解我国中老年自然人群颈-股动脉脉搏波速度（CFPWV）的分布及相关因素。方法对北京市石景山区1519名44—79岁居民进行心血管病危险因素调查及CFPWV测量。采用单因素方差分析、Pearson相关和偏相关、多元逐步回归分析CFPWV的相关因素。结果（1）调整年龄后，男女CFPWV均值分别为11．4m／s和11．1m／s，男性显著高于女性（P〈0．01）。无论男女，随着年龄增长，CFPWV增加，趋势检验有显著性（P〈0．01）。（2）调整年龄、性别后，高血压、糖尿病和心率较高组（≥70次／min）CFPWV显著高于非高血压、非糖尿病和心率较低组（〈70次／min）（P均〈0．01）。（3）简单相关显示：不论男女，年龄、收缩压、舒张压、空腹血糖、心率均与CFPWV显著相关，相关系数为0．12～0．46（P均〈0．01）；女性CFPWV还与总胆固醇、甘油三酯显著相关，相关系数为0．11和0．13（P均〈0．01）；多元逐步回归显示年龄、性别、收缩压、舒张压、空腹血糖、心率是CFPWV的独立相关因素，年龄是CFPWV最大的相关因素。结论我国中老年自然人群中，年龄、性别、收缩压、舒张压、空腹血糖、心率与CFPWV显著相关，高密度脂蛋白胆固醇、体质指数与CFPWV不相关。
Objective To explore the profile and related factors of carotid femoral pulse wave velocity （CFPWV） in a community-based Beijing population of middle and old age. Methods A total of 1519 residents aged 44 - 79 years old from Shijingshan district, Beijing, were recruited for the cardiovascular risk factor survey and CFPWV measurements. One way ANOVA, pearson correlation and partial correlation, stepwise multi-linear regression were used for the data analysis. Results （ 1 ） The age- adjusted mean value of CFPWV was significantly higher in men than that in women （ 11.4 vs. 11. 1 m/s, P =0. 007）. CFPWV increased significantly with age both for men and women （all P 〈 0. 01 ）. （2）After adjusting for age and gender, CFPWV was significantly higher in people with hypertension, diabetes and higher heart rate （ 〉 70 beats/min） than people without these factors （ P 〈 0. 01 ）. （3） CFPWV significantly correlated with age, systolic blood pressure, diastolic blood pressure, fasting blood glucose and heart rate （correlation coefficient ranged from 0. 12 - 0.46, all P 〈 0. 01 ） . In female, CFPWV was positively correlated with total cholesterol and triglycerides （ correlation coefficient 0. 11 and 0. 13, all P 〈 0. 01 ）. Multi-linear regression analysis showed age, gender, systolic blood pressure, diastolic blood pressure, fasting blood glucose and heart rate were independent predictors of CFPWV. Conclusion In this middle and old age Chinese population, age, sex, systolic blood pressure, diastolic blood pressure, fasting blood glucose and heart rate but not HDL-cholesterol and body mass index were associated with CFPWV.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2008年第12期1120-1124,共5页
Chinese Journal of Cardiology
基金
国家“十五”科技攻关课题项目资助（2001BA703B01）志谢 王梦琴、石林惠和陈伟协助测量CFPWV
关键词
动脉
弹性
中年人
老年人
Arteries
Elasticity
Middle age
Aged
