摘要
目的 探讨乳腺癌的临床病理特征及意义。方法对356例乳腺癌临床特点、病理特征及组织分型进行回顾性分析，并对所有病例进行PR、ER及CerbB-2染色。结果356例乳腺癌中，41-50a年龄组人数最多，占40．73％（145／356）。组织学以浸润性导管癌为主占87．64％（312／356）。ER阳性率59．27％（211／356），PR阳性率46．07％（164／356），CerbB-2阳性率66．85％（238／356）。CerbB-2随临床分期的递增和淋巴结转移数目的增多，其阳性率随之增加，差异有显著性（P〈0．05）。CerbB-2表达与ER、PR状况呈负相关，差异有显著性（P〈0．05）。结论乳腺癌是女性最常见的恶性肿瘤，与年龄、腋窝淋巴结转移情况、病理分型和免疫组化等有密切关系。因此，积极普及乳腺癌防治的宣传、早发现、早诊断、早治疗可提高治愈率和生存率。
Objective To study both the clinicopathologic features and the significance of the breast carcinoma. Methods 356 cases of breast carcinoma was analyzed about the clinical features, pathological characteristic and histological type. Then these cases were stained with ER, PR, or CerbB-2. Results Among the 356 cases of breast carcinoma, 41-50 year old of age group population are most, accounts for 40.73% （145/356）. In terms of tissue, the majority of the carcinoma infiltrating ductal carcinoma, which takes 87.64% （312/356）. The positive rate of ER was 59.27% （211/356）, that of PR was 46.07% （164/356）, and that of CerbB-2 was 66.85% （238/356）. With the increased number of clinical periods and shift of lumph nodes, the positive rate increased with obvious differences （P〈0.05） while CerbB-2 shows a neg-corelation to ER , PR obvious differences （P〈0.05）. Conclusions Breast carcinoma, which is themost common malignant tumor for women, relates closely to women＇s age, their shift of lymphnodes under the armpits, their types of pathology and their immunohistochemistry. So a higher percentage of cure and survival of breast carcinoma must be accompanied by a widespread knowledge on its prevention, a first recognition, an in-time diagnosis and an immediate treatment.
出处
《世界肿瘤杂志》
2008年第4期265-267,274,共4页
Tumour Journal of the World
关键词
乳腺癌
病理分析
免疫组化
Breast carcinoma
Clinicopathologic analysis
immunohistochemistry
