摘要
目的探讨中药胆囊2号方在腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)围手术期中的应用价值。方法360例行LC患者随机分为两组,每组各180例。治疗组围手术期应用中药胆囊2号方(木香10 g赤芍15 g虎杖10 g黄芩10 g金银花15 g连翘10 g生大黄9 g枳实10 g川朴10 g桃仁10 g丹参20 g甘草4 g)水煎服,每日1剂,自术前1天晚开始,对照组应用抗生素(头孢唑肟钠2.0 g或左氧氟沙星200 mg,静脉滴注,术前0.5 h预防性应用1次。术后根据具体病况应用同种抗生素1～3天),比较两组术后肠鸣音恢复时间,排气、排便时间,术后体温,输液天数,住院时间,术后感染并发症,手术前后白细胞计数,C-反应蛋白等指标。结果治疗组肠鸣音恢复时间、排气、排便时间分别为(10.42±4.38)h、(15.60±5.03)h及(38.81±9.87)h,均明显早于对照组[分别为(17.11±6.25)h、(32.74±9.43)h及(56.09±11.00)h],治疗组白细胞计数、C-反应蛋白、术后体温、输液天数、住院时间均明显低于对照组,差异有统计学意义(P<0.01或P<0.05)。两组术后感染并发症差异无统计学意义(P>0.05)。结论围手术期应用中药胆囊2号方可有效促进LC术后肠功能恢复,抑制急性炎症的发生。
Objective To explore the significance of application of Dannang Recipe No. 2 （DNR2）, a Chinese herbal preparation, in the perioperative period of laparoscopic cholecystectomy （LC）. Methods Three hundred and sixty patients with LC were randomly assigned to two groups,180 in each group. The treatment group was treated with DNR2 in the perioperative period, one dose of the recipe composed of aucklandia root 10 g, red peony root 15 g, giant knotweed rhizome 10 g, scutellaria root 10 g, honeysuckle flower 15 g, forsythia fruit 10 g, rhubarb 9 g, immature bitter orange 10 g, magnolia bark 10 g, peach kernel 10 g, red sage root 20 g and licorice root 4 g, which was boiled with water and taken one dose per day, starting from the previous night of operation. The control group was treated by antibiotic with Ceftizoxime sodium 2.0 g or Levofloxacin 200 mg via intravenous dripping once 0. 5 h before operation preventively and 1-3 days after operation according to patients＇ condition. The indexes, including recovery time of borborygmus, gas elimination and defecation, post-operation body temperature, days needing fluid transfu- sion, hospitalization time, incidence of infectious complication, as well as the white blood cell counting （WBC） and serum C-reactive protein （CRP） before and after operation, were analyzed and compared between groups. Results The recovery time of borborygmus, gas elimination and defecation were shorter in the treatment group as compared with that in the control group （10.42 ±4.38 h vs 17.11 ±6.25 h, 15.60 ±5.03 h vs 32.74 ±9.43 h and 38.81 ±9.87 h vs 56.09 ± 11.00 h, respectively） and all the other indexes were better in the treatment group than those in the control group, showing significant difference （P 〈 0. 01 or P 〈 0. 05）, except the incidence of postopera- tive infectious complication, it was similar in the two groups. Conclusion Application of DNR2 in perioperative stage of laparoscopic cholecystectomy can effectively promote the recovery of postoperative gastrointestinal motility and suppress the occurrence of acute inflammation.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2008年第12期1090-1092,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
胆囊切除术
腹腔镜
中药
围手术期
cholecystectomy
laparoscopy
Chinese herbal medicine
perioperative period
