摘要
目的研究新辅助化疗对Ⅲ期非小细胞肺癌(NSCLC)手术疗效、长期生存率及化疗和手术的相互影响,评价其安全性及可行性。方法32例Ⅲ期NSCLC患者随机分为A组16例和B组16例,A组患者确诊后接受2个周期的全身化疗,然后手术;B组患者确诊后直接手术治疗。比较2组疗效、长期生存率,评价术后化疗的毒性反应及对手术并发症发生的影响。结果A组与B组的手术切除率分别为94%和88%,无显著性差异;A组总有效率56%,B组总有效率31%,2组比较有显著性差异(P<0.05);A组与B组生存率比较,1 a存活、3 a存活无显著性差异(P>0.05),5 a存活有显著性差异(P<0.05);新辅助化疗并未增加不良反应和手术并发症。结论新辅助化疗可明显提高Ⅲ期NSCLC患者的手术疗效及远期生存率,值得临床上进一步推广使用。
Objective It is to study the influence of neoadjuvant chemotherapy on operative curative effect and long term survival rate of non-small cell lung cancer （NSCLC） in stage Ⅲ and the interaction between chemotherapy and operation, and to evaluate the safety and feasibility of neoadjuvant chemotherapy. Methods 32 patients with NSCLC in stage Ⅲ were divided into group A and group B in which there was 16 cases. Group A was received two cycle neoadjuvant chemotherapy af- ter final diagnosis and then had operation. Group B was received operation immediately after final diagnosis. The curative effect and long term survival rate in the two groups were compared. The toxic reaction of chemotherapy after operation and the influence on operation complication were evaluated. Results Resective in group A and group B were 94 % and 97 % respectively and there was no significant difference. The lungs lobectomy rate in group A was obviously higher than that in group B and the transfering rate of Mediastinal lymph node in group A was obviously lower than that in group B, and there was significant difference. The total effective rate in group A was 56 % and that in group B was 31%, there was significant difference between the two groups （P 〈 0.05）. The survival rate of the two groups was compared, and there were no significant differences on 1 a survival and 3 a survival （ P 〉 0.05 ） but there was significant difference on 5 a survival （ P 〈 0.05 ）. Neoadjuvant chemotherapy could not increase untoward reaction and operation complication. Conclusion Neoadjuvant chemotherapy can obviously elevate operative curative effect and long term survival rate of NSCLC patients in stage Ⅲ, which is worth spreading the clinical application extensively.
出处
《现代中西医结合杂志》
CAS
2009年第2期118-119,122,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
新辅助化疗
非小细胞肺癌
手术
neoadjuvant chemotherapy
non-small cell lung cancer
operation
