摘要
观察１１例烧伤病人血清免疫抑制作用与氧自由基的关系。结果显示：烧伤病人血清ＭＤＡ，ｓＩＬ－２Ｒ升高（Ｐ＜０．０１）；病人血清能抑制正常人ＰＢＭＣ产生ＩＬ－２（Ｐ＜０．０１）；抗氧化治疗可降低病人血清ｓＩＬ－２Ｒ水平和血清的抑制作用（Ｐ＜０．０５）。
The serum immunosuppresion effect and its relation to oxygen free radicals were studied in patients with thermal injury (n=11, total body surface area 20%～83%). The serum MDA, sIL2R increased significantly in burned patients (P<0.01 all). The serum of burned patients depressed the IL2 productin of normal human PBMC (P<0.01). Antioxidants decreased the serum sIL2R in burned paients and attenvated the suppressive effect IL2 production of normla human PBMC (P<0.05 all). The results suggest that oxygen free radicals participate in the serum immunosuppresion effect in burned patients.
出处
《湖南医科大学学报》
CSCD
1998年第1期103-105,共3页
Bulletin of Hunan Medical University
基金
国家自然科学基金
关键词
灼伤
血清
免疫抑制
氧自由基
burns
serum
immunosuppression
oxygen free radicals
