摘要
目的探讨大剂量甲基强的松龙治疗急性脊髓损伤的作用机理。方法４０只家兔分成３组，用改良Ａｌｅｎ法造成不完全性脊髓损伤，进行运动功能、脊髓诱发电位、血液流变学、脊髓丙二醛和病理对比观察。结果大剂量甲基强的松龙治疗组较损伤组运动功能的恢复显著提高，脊髓诱发电位波形分化较清晰，血液流变学明显改善，脊髓丙二醛含量下降，病理损害减轻。结论早期应用大剂量甲基强的松龙治疗脊髓损伤，可以改善脊髓组织的血液供应，减轻脊髓的继发性损伤，促进脊髓功能恢复。
Objective This study is to inquire into the mechanism of highdose methylprednisolone sodium succinate on acute spinal cord injury. Methods Forty rabbits were subjected to incomplete spinal injury and devided into three groups. The movement function, spinal cord evoked potentials, hemorheology, spinal cord malondiadehyde and pathologic histology were observed and compared among different groups. Results It is demonstrated that in the therapeutic group, the movement function was obviously increased, spinal cord evoked potentials were emergent again, the hemorheology was significantly inproved, the content of spinal cord malondiadehyde was reduced and pathologic injury was lightened compared with the injury group. Conclusions The experiment advanced that the treatment of spinal cord injury in early stage by highdose methylprednisolone could improve blood supply of spinal cord tissue, reduce spinal cord secondary injury and promote spinal cord function recovery.
出处
《安徽医科大学学报》
CAS
1998年第1期20-22,共3页
Acta Universitatis Medicinalis Anhui
关键词
脊髓损伤
药物疗法
甲基强的松龙
eSH spinal cord injuries/drug ther
methylprednisolone/ther used
evoked potentials
hemorheology
malondiadehyde
rabbits
