摘要
Objective： To observe the changes of 5-hydroxytryptamine （5-HT） in colonic membrane of diarrhea-predominant irritable bowel syndrome （IBS-D） and the clinical efficacy of herbal cake-partitioned moxibustion in treating it, and to explore the action mechanisms. Methods： Seventy-three subjects were randomized into two groups： moxibustion group in which 37 cases were treated by herbal cake-partitioned moxibustion and needling group in which 36 cases were treated by needling. The clinical efficacy and 5-HT expression in colonic membrane were observed. Results： The cure rate was 43.2% in the moxibustion group and 36.1% in the needling group, with no significant difference between the two groups （P〉0.05）. Herbal cake-partitioned moxibustion could reduce 5-HT expression in colonic membrane. Conclusion： Herbal cake-partitioned moxibustion might improve the clinical symptoms of IBS-D by reducing 5-HT expression.
目的:观察腹泻型肠易激综合征(irritable bowel syndrome,IBS)患者结肠粘膜5-HT 变化及隔药灸治疗的临床疗效,初步探讨其作用机理。方法:临床收集腹泻型 IBS 患者73例,随机分为隔药灸组(37例)和针刺组(36例)进行治疗,观察临床疗效,并观察隔药灸治疗对典型患者结肠粘膜5-HT 表达的影响。结果:隔药灸组痊愈率为43.2%,针刺组痊愈率为36.1%,两组间无统计学差异(P>0.05);隔药灸治疗能够改善患者结肠粘膜5-HT 异常增高的表达。结论:隔药灸能够改善腹泻型 IBS 临床症状,可能是通过调节5-HT 表达发挥治疗作用。
基金
State Administration of TCM of RR.China(2003ZL23)
Shanghai Leading Academic Discipline Project
