摘要
目的探讨和总结小儿药物难治性癫痫患者外科治疗的时机和疗效。方法分析240例小儿癫痫外科治疗后早期和远期的临床疗效和随访资料。结果本组术后早期癫痫无发作228例，占95．0％。随访1年以上的170例中，Ende评分：Ⅰ级98例（57．6％），其中Ⅰa级70例（41．1％）；Ⅱ级40例（23．5％）；Ⅲ级20例（11．8％）；Ⅳ级12例（7．1％），无死亡和永久性并发症。结论小儿癫痫患者早期的外科干预，可能在小儿大脑发育的可塑性期内解除致痫因素，有望获得良好的预后和智商水平的维持与提高。
Objective To determine the timing and effects of epilepsy surgery in children with medically intractable epilepsy. Methods We collected the early and late outcomes of 240 pediatric cases that underwent epilepsy surgery in our department from September 2001 to September 2007. Results 95% （228 cases ）patients became seizure free during early postoperative period. 170 cases were followed up for more than 1 year and their outcomes were graded by Engle＇ scale. 98 cases （57.6%） were scaled as Grade Ⅰ , 70 cases （41. 1% ） as Grade Ⅰa, 40 cases（23.5% ） as Grade Ⅱ , 20 cases （ 11.8 % ） as Grade Ⅲ, and 12 cases （7.1 % ） as Grade Ⅳ. No death or permanent disability occurred. Conclusions The timing of surgery to pediatric epilepsy is controversial. The epilepsy surgery may eliminate the epigenetic lesions before the brain matures, which may help the maintenance and improvement of IQ, leading to a better prognosis.
出处
《中华神经外科杂志》
CSCD
北大核心
2008年第12期925-927,共3页
Chinese Journal of Neurosurgery
关键词
癫痫
儿童
外科手术
预后
Epilepsy
Child
Surgical procedures,operative
Prognosis
