摘要
目的比较米索前列醇配伍米非司酮两种给药间隔终止中期妊娠的效果,探讨两种药物的最佳给药间隔。方法妊娠12～16周、要求药物终止妊娠的健康孕妇100例,随机均分为A、B两组。A组口服米非司酮200 mg,36～48 h后阴道放置米索前列醇600μg,3 h后阴道放置米索前列醇400μg,每3 h 1次,共4次。B组口服米非司酮200 mg,同时阴道放置米索前列醇600μg,3 h后阴道放置米索前列醇400μg,每3 h 1次,共4次。结果A组从应用米索前列醇开始到孕囊排出时间为(314.0±139.5)min,显著短于B组的(513.8±220.0)min(P<0.01)。A组米索前列醇总用量为(1 008.0±285.6)μg,显著低于B组的(1 512.0±302.8)μg(P<0.01)。A组从用米索前列醇开始到孕囊排出时的最高体温为(37.35±0.58)℃,显著低于B组的(38.27±0.90)℃(P<0.01)。结论对于终止中期妊娠,与同时应用米非司酮和米索前列醇比较,米非司酮作用36～48 h后再予米索前列醇具有米索前列醇用量少、孕囊排出时间短及用药时最高体温低的优点。
Objective To compare the effect of misoprostol administered at different intervals and mifepristone for termination of second trimester pregnancy, so as to know the optimal administration of the 2 agents. Methods A total of 100 healthy women at 12-16 w of pregnancy, who were seeking to terminate pregnancy with medical abortion, were randomized into group A （n=50） and B （n=50）. Initially, both group had mifepristone 200 mg orally. Women in group A also received misoprostol 600 μg vaginally after 36--48 h, then misoprostol （400 μg in each dose, 4 doses as maximal） were vaginally given every 3 h after previous administration. Women in group B received misoprostol 600 μg vaginally together with mifepristone, then misoprostot （400 μg in each dose, 4 doses as maximal） were vaginally given every 3 h after previous administration. Results Women in group A expelled gestational sac within （314.04± 139.52） min on average, which was significantly shorter than that in group B （[513.8 ± 220.04] min, P〈0.01）. The mean dosage of misoprostol was （1 008.0 ± 285.6） μg for women in group A and （1 512.0±302.8） μg in group B （P〈0.01）. Mean body peak temperature for groupAwas （37.35±0.58） ℃, significantly lower than that in group B （[38.27±0.90]℃ , P〈 0.01）. Conclusion When combined with mifepristone, misoprostol is more effectively in second trimester pregnancy termination if applied 36- 48 h after mifepristone administration, and the total doses of misprostol in women is reduced and the expel of gestational sac is quicker, with the peak body temperature of patients decreased.
出处
《上海医学》
CAS
CSCD
北大核心
2008年第12期866-868,共3页
Shanghai Medical Journal
关键词
米索前列醇
米非司酮
中期妊娠
引产
Misoprostol
Mifepristone
Second trimester pregnancy
Pregnancy termination
