摘要
为了探讨细胞凋亡抑制基因ｂｃｌ２和促进基因ｂａｘ在前列腺增生（ＢＰＨ）发病中的作用，应用免疫组化ＳＰ方法对５４例ＢＰＨ组织和１８例正常前列腺组织（ＮＰ）中ｂｃｌ２和ｂａｘ的表达进行检测。ｂｃｌ２和ｂａｘ在ＮＰ和ＢＰＨ的上皮及间质中均有表达。ＢＰＨ中ｂｃｌ２表达明显高于ＮＰ，ＮＰ上皮细胞中ｂａｘ表达高于ＢＰＨ上皮细胞，两者间质中表达无显著性差异。ＮＰ中ｂａｘ表达显著高于ｂｃｌ２表达，而ＢＰＨ上皮细胞中ｂｃｌ２表达显著高于ｂａｘ表达，间质中两者表达无显著性差异。ＮＰ和ＢＰＨ中ｂｃｌ２与ｂａｘ表达之间均呈正相关且两者在分布定位上基本一致。结果表明ｂｃｌ２和ｂａｘ在ＢＰＨ的发生发展过程中起着重要作用，并且与前列腺细胞凋亡的调节过程有关。
The distribution and expression of bcl2 and bax were studied by means of immunohistochemical SP technique in 54 cases of BPH and in 18 normal prostatic tissue(NP). Both expressions were found in the epithelium and stroma of BPH and NP tissues. bcl2 expression was significantly higher in BPH than in NP while bax expression in NP epithelium was higher than that in BPH epithelium. There has been no significant difference of both the expressions in the stroma of BPH and NP. The result indicates that the apoptosis genes bcl2 and bax play a role in the development of BPH and in the regulation of prostatic apoptosis.
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
1998年第2期98-100,共3页
Chinese Journal of Urology
关键词
前列腺增生
细胞凋亡
免疫组化
Prostatic hypertrophy Apoptosis Immunnohistochemistry
