摘要
目的:筛选制备高载药量和释放性能良好的丝裂霉素微囊的条件。方法:以溶剂非溶剂法制备了丝裂霉素微囊,用高效液相色谱法和紫外分光光度法测定丝裂霉素微囊载药量及释放度。结果:随着囊材用量减少,载药量升高,释放显现突释效应;随着吐温-80用量的增加,释放度逐渐加快,直至无规律释药;随着搅拌速度的加快,载药量先增加后减少,释放度增大。结论:以正己烷、环己烷为溶剂,最佳制备工艺条件是:0.8%的乙基纤维素,4%的吐温-80,100 r.min-1的搅拌速度。
Objective：To prepare mitomycin microcapsule with high drug loading rate and sustainedrelease character. Methods： Mitomycin microcapsule was prepared using solvent and solventless method. The concentrations and release rate of mitomycin were measured by HPLC and ultraviolet-visible spectrophotometry. Results： The results showed that the loading rates were increased as the ethylcellulose decreased; the release rate was increased as the tween-80 increased; the loading rates were increased in the beginning then decreased and release rate was increased as the churning speed was increased. Conclusion ： The conditions of the best preparation technology are as follows ： 0.8% ethylcellulose, 4% tween-80, churning speed of 100r· min^-1.
出处
《药学与临床研究》
2008年第6期478-480,共3页
Pharmaceutical and Clinical Research
基金
科技部技术创新基金项目(04C26213300548)
关键词
丝裂霉素微囊
制备条件
载药量
释放度
Mitomycin microcapsule
Preparation conditions
Drug loading rate
Release rate
