摘要
目的:以山嵛酸甘油酯为载体材料制备青藤碱固体脂质纳米粒并评价其质量。方法:采用乳化蒸发-低温固化法制备青藤碱固体脂质纳米粒,以正交设计优化其处方和制备工艺。对其粒径、形态、表面电位、包封率等理化性质进行研究,并考察其稳定性。结果:所制固体脂质纳米粒外观形态圆整,平均粒径为208.7nm,Zeta电位为-38.5mV,平均包封率为65.7%。4℃放置2个月,粒径、包封率无明显变化。结论:青藤碱固体脂质纳米粒的制备,为开发其新制剂奠定了实验基础。
OBJECTIVE To prepare sinomenine-loaded solid lipid nanoparticles with docosanoic acid glyceride as its lipid matrix and investigate its quality. METHODS An emulsification- solvent evaporation technique was adopted to prepare sinomenine-loaded solid lipid nanoparticles and the orthogonal design was applied to optimize its formula and lechnology. The mean particle size, drug loading capacity, drug entrapment efficiency （EE%）, zeta potential, and long-term physical stability of the SLN were investigated. RESULTS The obtained solid lipid nanoparticles were round, smooth particles with average size of 208. 7 nm, zeta potential - 38.5 mV and entrapment efficiency 65.7%. There were no obvious changes of the particle size and entrapment efficiency at 4 ℃ within one month. CONCLUSION The SLN can be used as new sustained release preparation for Sinomenine.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2008年第24期2081-2084,共4页
Chinese Journal of Hospital Pharmacy
基金
湖北省科技攻关项目(编号2006AA301C02)
关键词
青藤碱
固体脂质纳米粒
制备工艺
sinomenine
solid lipid nanoparticles
preparation technique
