摘要
目的探讨碘克沙醇对重度肾功能不全患者的影响。方法回顾性分析住院行冠状动脉造影及介入治疗126例患者的资料,根据造影剂的选择将受试者分为等渗造影剂-碘克沙醇组(A组),72例;低渗造影剂-碘海醇组(B组),54例。比较2组患者的临床特点、造影前后血清肌酐(Scr)和肌酐清除率(Ccr)的变化、造影剂肾病(CIN)的发生率以及近期预后。结果慢性肾功能不全患者发生CIN的危险因素在2组间差异无统计学意义;2种造影剂均可能引起Scr的增高及Ccr的下降,导致CIN的发生,但碘克沙醇组CIN发病率明显低于碘海醇组(4.2%vs29.6%,P<0.05);6例受试者发生不良反应,其中碘海醇组5例,碘克沙醇组1例。结论与低渗性造影剂相比,等渗性造影剂可以降低Scr水平及RCIN的发病率,减少不良事件的发生,适用于慢性肾功能不全患者或合并糖尿病患者。
Objective To discuss the effects of lodixanol on patients with moderate to severe renal failure. Methods One hundred and twenty-six patients who had undergone coronary angiography and intervention were retrospectively analyzed. These 126 cases were divided into group A （72 cases, using lodixanol） and group B （54 cases, using iohexol）. Between group A and B, the clinical features, serum ereatinine（ Ser）, creatinine clearance rates（ Cer）, and mobidity rates and prognosis of radioeontrast induced nephropathy （CIN） were compared. Results There was no difference in pre-procednre risk factors of CIN between group A and B. In both groups there were Scr increasing and Ccr decreasing which caused CIN. However, the CIN rates were lower in group A than in group B（4.2% vs 29.6% , P 〈 0.05 ）. There were 6 cases of adverse effects, 5 of them were in group B. Conclusion Comparing with hypotonic contrast agents, the isotonic contrast agents could lower Ser baseline level and CIN occurrence rates, at the same time adverse effects can be reduced especially in patients with chronic renal failure or diabetes.
出处
《首都医科大学学报》
CAS
2008年第6期758-761,共4页
Journal of Capital Medical University
关键词
慢性肾功能不全患者
碘克沙醇
造影剂肾病
不良事件
patients with chronic renal failure
lodixanol
contrast-induced ncphropathy
adverse effects
