摘要
目的比较丙泊酚靶控输注(TCI)复合瑞芬太尼全凭静脉麻醉和七氟醚复合瑞芬太尼麻醉对单次插管剂量顺式阿曲库铵肌松效应的影响。方法ASAⅠ或Ⅱ级的择期全麻患者48例,随机均分为丙泊酚(P)组和七氟醚(S)组。麻醉诱导后予0.6 mg/kg的顺式阿曲库铵插管;P组和S组麻醉维持分别采用丙泊酚TCI-泵注瑞芬太尼和吸入1 MAC七氟醚泵注瑞芬太尼。监测脑电双频指数(BIS),使用加速度肌松监测仪观察拇内收肌的收缩反应,记录顺式阿曲库铵的起效时间、无反应时间、肌松维持时间及恢复指数等指标。结果两组之间肌松起效时间、无反应时间及T125%时间差异无统计学意义,Ⅰ组25%四个成串刺激比(TOFr)及恢复指数都比P组明显延长(P<0.05)。结论单次插管剂量的顺式阿曲库铵在丙泊酚TCI泵注瑞芬太尼麻醉下肌松维持及恢复无明显变化,而在吸入1 MAC七氟醚.泵注瑞芬太尼麻醉下恢复时间明显延长。
Objective： To investigate the neuromuscular effect of cisatracurium underpropofol Target controlled infusion （TCI） anesthesia or sevoflurane anesthesia. Methods： Forty-eight ASA class Ⅰ or Ⅱ group P, paLienls undergoing selective operations（n = 24 ） and Sevooflurane inhalation group （group S n = 24） were randomly divided into propofol TCI and sevoflurane groups （group S n =24）. Methods： Forty eight patients undergoing selective surgeries were randomized into two groups. After intravenous midazoline 0. 15 mg·kg^-1 and fentanyl 4 μg·kg^-1, anesthesia maintenance was achieved by sevoflurane inhalation end-tidal concentionl. 7 Vol% in group S and remifentainyl（ n = 24 ） , patients in group P were maintained by propofol Target controlled and remifentainyl （n =24sinfusion）. In all groups neuromusclecular was induced by rocuronium and monitored by using train-of-four（TOF） stimulation ulnar nerve. The onset time,no response time, the time recovering to 25% of control, recover index and TOF ratio（ TOFr to 0.25） were recorded. Results： The no response time, the time recovering to 25% of control, recover index and TOF ratio（ TOFr to 0.25 ） were great longer than those in propofol-remifentainyl group. （P 〈 0. 05）. But there was no difference in the onset time between the two groups. Conclusion： Propofol TCI-remifentainyl has no effect on neuromuscular of cisatracurium 1 MAC sevoflurane can potentiate the neuromuscular of cisatracurium.
出处
《泰山医学院学报》
CAS
2008年第10期787-788,共2页
Journal of Taishan Medical College
