摘要
目的探讨不同剂量长托宁用于剖宫产手术麻醉前用药的安全性和有效性,为术前合理应用抗胆碱能药物提供依据。方法择期拟行剖宫产手术的患者75例用信封法随机分成3组,每组25例。Ⅰ组,患者术前30min肌肉注射长托宁0.5mg,Ⅱ组,患者术前30min肌肉注射长托宁0.01mg/kg,对照组患者术前肌注生理盐水。记录注射后10、20、30min患者的MBP,心率,VAS评分和新生Apgar评分。结果Ⅰ组和Ⅱ组患者口干VAS评分分别与用药前比较差异有统计学意义。注射后10、20、30min两组之间VAS评分差异无统计学意义;3组患者在用药后各时点平均动脉血压和心率均差异无统计学意义(P>0.05),但心率与基础值比较有减慢的趋势;3组患者新生儿Apgar评分差异无统计学意义。结论术前肌肉注射长托宁0.01mg/kg组和肌肉注射长托宁0.5mg组对产妇血压和心率均无明显影响,均可安全用于剖宫产术麻醉前给药。
Objective To investigate influence of different dosage of penehyclidine hydrochloride on the thirstiness,blood pressure and heart rate before anesthetizing the pregnant woman for eeaurean delivery. Methods 75 pregnant women for cesarean section were enrolled and they were randomly and equally divided into three groups. In penehyclidine hydrochloride first group, penehyclidine hydrochloride（0.5mg） was injected intramuscular thirty minutes before anesthetizing the pregnant woman for ceaurean delivery. In penehyclidine hydrochloride second group, penehyclidine hydrochloride（0.01 mg/kg） were injected intramuscular. In the control group, sodium chloride was injected. Heart rate{HR}, mean blood pressnre（MBP） and A Pagar score were recorded, and chirstiness was evaluted by VAS every 10 min afterintramuscular injection. Results The VAS of the penehyclidine hydrochloride first and second group were increased significantly when compared to base-line values.HR and MBP and Apagar score showed no evident changes among the groups during the investigation（ P 〉 0.05 ）. But HR had a tendency of decrease in all penehyclidine hydrochloride grops. Conclusion Intramuscular injection of penehyclidine hydrochloride（ 0.5rag or 0.01 mg/kg）before anesthetizing the pregnant woman for ceanrean delivery were safety.
出处
《四川医学》
CAS
2008年第12期1626-1627,共2页
Sichuan Medical Journal
关键词
长托宁
剖宫产手术
麻醉
疗效
penehyelidine hydrochloride
uterine-incision delivery
anesthesia
curative effect
