摘要
大多数抗骨质疏松药物只能抑制骨吸收而不能促进骨的形成。雷奈酸锶是目前为止唯一具有"双重作用"的抗骨质疏松药物,既能抑制骨的吸收又能促进骨的形成。通过检索文献,文章从药理实验、临床研究及作用机制3方面总结骨吸收中雷奈酸锶的作用和研究进展。
Most of anti-osteoporosis drugs can only inhibit bone resorption, but can not improve the bone formation. So far, Strontium ranelate is the only anti-osteoporosis drug that has a dual effect on bone resorption and bone formation. Through the retrieval of related studies, the present review article evaluates the current understanding of strontium ranelate effects on bone resorption based on the pharmacologic experiments, clinical studies, action mechanisms. Recombinant human bone morphogenetic protein-2 （rhBMP-2） has been widely used on clinic; however, there are still few reports addressing rhBMP-2-induced osteogenesis in intervertebral disc.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2008年第50期9993-9996,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
