摘要
目的研究华支睾吸虫病患者的流行病学和临床特征。方法对哈尔滨医科大学附属第二医院2002至2004年收治88例华支睾吸虫病患者的流行病学资料、临床表现、实验室检查、治疗情况进行回顾性分析。结果有进食生的或半生的淡水鱼（虾）史的患者占68．2％，22．6％的患者职业为厨师、喂鱼员、钓鱼爱好者、鱼贩，9．1％的患者传播途径未明。88例患者中，上腹疼痛53例，占60．3％；乏力46例，占52．3％；腹泻29例，占33．0％；食欲减退61例，占69，3％；黄疸21例，占23．9%；肝脏肿大52例，占59．1％；脾脏肿大7例，占8．0％；头晕18例，占20．9％；发热5例，占5．7％；胆绞痛13例，占14．8％；28．4％的患者无症状。嗜酸粒细胞增多61例，占69．3％；肝功能异常62例，占70．4％。吡喹酮、丙硫咪唑治疗组的粪便虫卵阴转率分别为91．9％，86．5%（X2=0．561，P=0．454）。结论华支睾吸虫病临床表现复杂、多样，常出现肝功能异常，易误诊，值得重视。
Objective To investigate epidemiological and clinical features of patients with clonorchiasis sinensis infection. Methods The epidemiological, clinical, laboratory and treatment data of clonorchiasis patients in Department of Infectious Diseases, Second Affiliated Hospital, Harbin Medical University from 2002 to 2004 were retrospectively analyzed. Results Sixty-eight point two percent patients had a history of eating raw freshwater fish and shrimp. Patients with occupations as cook, fish stock man, fishing man and fishmonger accounted for 22.6%. The transmission route was not clear in 9. 1% of patients. The common clinical manifestations were abdominal pain （60.3 % ）, fatigue （52.3%）, diarrhea （33.0%）, anorexia （69.3%）, jaundice （23.9%）, hepatomegaly （59.1%）, splenomegaly （8. 0%）, dizziness （20. 9%）, fever （5. 7%） and biliary colic （14.8%）. Twenty-eight point four percent were asymptomatic. Other findings included liver dysfunction （70.4 %） and eosinophile granulocyteosis（69.3 %）. Negative rate of stool egg of clonorchis sinensis after treatment with praziquantel or albendazole was 91.9% or 86.5%, respectively. There was no significant difference between the two groups （X2=0. 561, P = 0. 454）. Conclusions Clinical manifestations of patients with clonorchiasis sinensis are complicated and often accompanied with liver dysfunction. Clonorchiasis sinensis is often misdiagnosed and should be paid much attention.
出处
《中华传染病杂志》
CAS
CSCD
北大核心
2008年第12期744-746,共3页
Chinese Journal of Infectious Diseases
