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总量统计矩相似度法对左金缓释片多成分释放相似度的评价研究 被引量:24

Evaluation of release similarity of multicomponents in Zuojin Sustained-Release Tablet by the total quantum statistical moment similarity
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摘要 目的:研究左金缓释片释放规律及评价方法。方法:采用总量统计矩相似度法评价左金缓释片体外溶出液指纹图谱的相似性。结果:于1h至12h不同时间点所获左金缓释片溶出液指纹图谱的零阶矩、一阶矩、二阶矩的平均值分别为:2.620×10^8μv·sec、74.599min、252.481min。;RSD分别为62.445%、1.268%、2.777%。与全溶样品指纹图谱相比,各时问点溶出指纹图谱相似度的最小至最大值为0.947~0.991,平均值为0.977,RSD为1.491%。结论:总量统计矩相似度法能评价中药控缓释制剂多成分整体溶出规律,控制其质量。 AIM: To study and evaluate release rules of Zuojin Sustained-Release Tablet(ZJSRT). METHODS: The total quantum statistical moment similarity (TQSMS)was used to evaluate similarity of the chromato- graphic fingerprints of ZJSRT in vitro dissolution; RESULTS: Compared with the chromatographic fingerprint of the complete dissolution sample , the averages of area under curve of total quantum, mean chromatographic retention time of total quantum and variance of mean chromatographic retention time of total quantum of the ZJSRT' s release rules in vitro, from 1 to 12 h, were 2. 620 × 10^8 μv · see, 74. 599 rain and 252. 481 min^2 respectively, meanwhile their RSD were 62. 445% 、 1. 268% and 2. 777% coincidently, the similarities range from 0. 947 to 0. 991 ,as average of 0. 977 and RSD of 1. 491%. CONCLUSION: It is suggested that the TQSMS can evaluate release rules of muhieompon and control its quality.
出处 《中成药》 CAS CSCD 北大核心 2009年第1期35-39,共5页 Chinese Traditional Patent Medicine
基金 国家自然科学基金项目(30472199,30572678)
关键词 总量统计矩相似度 指纹图谱 左金缓释片 中药缓释制剂 total quantum statistical moment similarity (TQSMS) chromatographic fingerprints Zuojin Sustained-Release Tablet(ZJSRT) sustained-release preparation of traditional Chinese material medica(SRPTCMM)
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