6Davis HL,McCluskie MJ,Gerin JL, et al . DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines[J]. Proc Natl Acad Sci U S A, 1996 Jul 9,93(14):7 213-7 218.
7Mancini M, HadchouelM,DavisHL, et al . DNA-mediated immunization in a transgenicmousemodel ofthe hepatitis B surface antigen chronic carrier state[J]. Proc Natl Acad Sci U S A, 1996 Oct 29, 93(22) :12 496-12 501.
8Mancini-Bourgine M, Fontaine H, Scott-Algara D, et al.Induction or expansion of T-cell responsese by a hepatitis B DNA vaccine administered to chronic HBV carriers [ J ]. Hepatology, 2004, 40 :874-882.
10Vitielio A,Ishioka G,Grey HM, et al . Development of a lipopep- tide-based therapeutic vaccine to treat chronicHBV infection. I In duction of a primary cytotoxie T lymphocyte response in humans [J]. J Clin Invest, 1995,95: 341-349.
5Ishioka G Y, Fikes J, Hermanson G, et al. Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes[J]. J Immunol, 1999, 162(7):3915-3925.
6Roy M J, Wu M S, Barr L J, et al. Induction of antigen-specific CD8 + T cells, T helper cells, and protective levels of antibody in humans by particle-mediated administration of a hepatitis B virus DNA vaccine[J]. Vaccine, 2000, 19(7-8) : 764-778.
7Li X, Yang X, Jiang Y, et al. A novel HBV DNA vaccine based on T cell epitopes and its potential therapeutic effect in HBV transgenie mice[J]. Int Immunol, 2005, 17(10) : 1293- 1302.
8Depla E, Van der Aa A, Livingston B D, et al. Rational design of a multiepitope vaccine encoding T-lymphocyte epitopes for treatment of chronic hepatitis B virus infections[J]. J Virol,2008, 82(1) :435-450.
9Dawson D V, Ozgur M, Sari K, et al. Ramifications of HLA Class I Polymorphism and Population Genetics for Vaccine Development[ J]. Genetic Epidemiology, 2001, 20( 1 ) : 87-106.