摘要
测定了36例肝硬化患者，26例急性肝炎和25例正常人的外周血白细胞（WBC）吞噬功能、血浆纤维连结蛋白（Fn）和内毒素及血清C3等。并进一步探讨了WBC吞噬功能与其它指标问的相互关系。结果表明；肝硬化和急性肝炎患者WBC吞噬率明显低于正常对照，而血浆内毒素则明显高于对照，并与吞噬率呈明显负相关。同时，肝硬化病人血浆Fn明显低于树照组且与其WBC吞噬率呈明显正相关。上述结果提示，急慢性肝病患者易合并感染主要因其WBC吞噬功能减退，而后者与血浆Fn浓度的降低及存在内毒素血症（ETM）有重要关系。
Leukocyte phagocytosis and plasma fibronectin (Fn) and endotoxin levels were determined in 36 patients with hepatocirrbosis, 26 patients with acute hepatitis and 25 normal controls, and the relationship between leukocyte phagocytosis and plasma Fn and endotoxin levels were studled in these patients. The results showed that in comparison with controls, patients with hepatocirrhosis and acute hepatitis had lewer rate of leukocyte phagocytosis and higher plasrna endotoxin levels, and the rate leukocytc phagocytosis was inversely correlated with plasma endotoxin levels. Plasma Fn levels in patients with hepatocirrbosis and hepatitis were lower than those of controls, and was positively correIated with rate of leukocyte phagocytosis. The results suggest that decreased leukocyte phagocytosis rate may relate to low concentrafions of plasma Fn concentrations and endotoxin.
出处
《重庆医学》
CAS
CSCD
1998年第2期73-74,共2页
Chongqing medicine
关键词
肝疾病
白细胞吞噬功能
纤维连结蛋白
内毒素
acute and chronic hepatopathy, leukocyte phagocytosis, fibronectin(Fn),endotoxin
