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肾损伤分子-1在肾小管损伤中的表达 被引量：2

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摘要 肾损伤分子-1（Kidneyinjury molecule-1，KIM-1）是多种急性肾损伤（Acute kidney injury，AKI）早期特异和敏感的标志物．近期研究表明，对肾组织及尿液中KIM-1的检测有助于诊断和鉴别AKI，其应用价值优于血肌酐（Scr）和尿素氮（BUN），此外，KIM-1还参与肾小管E皮细胞的增殖、修复、转分化及肾间质的纤维化过程。本文对近期KIM-1的研究作一综述。
作者 邱杰山(综述) 朱晓玲(审校) 王永钧(审校)
机构地区 浙江中医药大学
出处 《国际泌尿系统杂志》 2009年第1期112-115,共4页 International Journal of Urology and Nephrology
关键词 肾小管 肾疾病
分类号 R692 [医药卫生—泌尿科学]
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参考文献25

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同被引文献21

  • 1Wu I, Parikh CR. Screening for kidney diseases: older measures versusnovel biomarkers [J] Clin J Am Soc Nephrol, 2008,3 ( 6 ) : 1895-1901.
  • 2孔岩,杨建梅,徐国宾,李淑葵,张春丽,郭晓蕙.对2型糖尿病患者肾小球滤过功能的评价[J].中华检验医学杂志,2007,30(11):1219-1222. 被引量：39
  • 3Fehrman-Ekholm L, Seeberger A, Bjork J, et al. Serum cystatin C:a useful marker of kidney function in very old people[J]. Scand J Clin Lab Inwest, 2009,69 (5) : 606.
  • 4Weinert LS,Prates AB,do Amaral FB, et al. Gender does not in fluence cystatin C concerntrations in healthy volunteers[J]. Clin Chen Lab Med,2010,48(3) :405-408.
  • 5Ogawa Y, Goto T, Tamasawa N, et al. Serum cystatin C in diabet- ic patients not only an indicator for renal dysfunction in patients with overt nepbropathy but also a predictor for cardiovascular e- vents in patiants without nephropathy [J]. Diahetes Res cl.in Pract,2008,79(2) :357-361.
  • 6Dieterle F, Perentes E, Cordier A, et al. Urinary clusterin, cystatin C,132-microglobulin and total protein as markers to detect drug-in duced kidney injury[J]. Nat Biotechnol, 2010, 28(5) : 463-469.
  • 7Malyszko J. Biomarkers of acute kidney injury in different clinicaI settings a time to change the paradigm[J]. Kidney Blood Press Res,2010,33:368-382.
  • 8Polat M,Fidan K,Definoz O, et al. Neutrophil gelatinase-as- sociated lipocalin as a follow-up marker in critically ill pediat: ric patients with established acute kidney injury[J]. Ren Fail, 2013,35(3) : 352-356.
  • 9许娟,亓文波.糖尿病肾病的肾小管损伤研究进展[J].国际内分泌代谢杂志,2008,28(2):123-125. 被引量：4
  • 10郑春霞,刘志红,芦怡舟,陈朝红,曾彩虹,黎磊石.局灶节段性肾小球硬化患者肾小管上皮细胞白细胞介素13受体表达与组织损伤的关系[J].肾脏病与透析肾移植杂志,2009,18(1):20-26. 被引量：7

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国际泌尿系统杂志
2009年 第1期

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