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3-me-DAB诱发大鼠肝癌发生过程中的形态学特点及GST-P的表达特征 被引量：1

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摘要 目的:研究在实验性肝癌发生、发展过程中病理形态学特征及GST-P mRNA的表达特点。方法:用0.06%3-甲基-4-甲基氨偶氮苯(3-me-DAB)饲喂SD大鼠制作肝癌模型,并在不同阶段处死大鼠取得肝脏标本。用RT-PCR技术检测肝癌模型各阶段GST-PmRNA的变化特征。结果:在3-me-DAB诱发大鼠肝癌发生过程中,肝脏卵圆细胞呈现一个从量变到质变的过程;随着肝癌的发生和发展,GST-PmRNA的表达呈递增趋势。结论:卵圆细胞有可能是肝癌的始动细胞;GST-P可作为一个分析和评价肝癌进程的重要标记酶;GST-P的表达是在基因水平上调控的。
作者 向锦 陈健智 赵国强
机构地区 中山大学肿瘤防治中心病理科 南海区人民医院病理科 中山大学病理学教研室
出处 《实用医学杂志》 CAS 北大核心 2009年第2期202-204,共3页 The Journal of Practical Medicine
关键词 肝肿瘤 大鼠 模型 动物 硫基转移酶类
分类号 R735.7 [医药卫生—肿瘤] R285.5 [医药卫生—中药学]
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  • 1Li Hou Ying Li Yong-Hua Jia Bo Wang Yi Xin Mao-Ying Ling Shen Lü Department of Pathology,Dalian Medical University,Dalian 116027,Liaoning Province,ChinaDepartment of Biochemistry,Dalian Medical University,Dalian 116027,Liaoning Province,China.Molecular mechanism about lymphogenous metastasis of hepatocarcinoma cells in mice[J].World Journal of Gastroenterology,2001,7(4):532-536. 被引量：47
  • 2[35]Aishima S,Kuroda Y,Asayama Y,Taguchi K,Nishihara Y,Taketomi A,Tsuneyoshi M.Prognostic impact of cholangiocellular and sarcomatous components in combined hepatocellular and cholangiocarcinoma.Hum Pathol 2006; 37:283-291
  • 3[36]Tanaka S,Yamamoto T,Tanaka H,Kodai S,Ogawa M,Ichikawa T,Hai S,Sakabe K,Uenishi T,Shuto T,Kubo S.Potentiality of combined hepatocellular and intrahepatic cholangiocellular carcinoma originating from a hepatic precursor cell:Immunohistochemical evidence.Hepatol Res 2005; 32:52-57
  • 4[37]Kim H,Park C,Han KH,Choi J,Kim YB,Kim JK,Park YN.Primary liver carcinoma of intermediate (hepatocyte-cholangiocyte) phenotype.J Hepatol 2004; 40:298-304
  • 5[38]Robrechts C,De Vos R,Van den Heuvel M,Van Cutsem E,Van Damme B,Desmet V,Roskams T.Primary liver tumour of intermediate (hepatocyte bile duct cell) phenotype:a progenitor cell tumour? Liver 1998; 18:288-293
  • 6[39]Koh KC,Lee H,Choi MS,Lee JH,Paik SW,Yoo BC,Rhee JC,Cho JW,Park CK,Kim HJ.Clinicopathologic features and prognosis of combined hepatocellular cholangiocarcinoma.Am J Surg 2005; 189:120-125
  • 7[40]Yano Y,Yamamoto J,Kosuge T,Sakamoto Y,Yamasaki S,Shimada K,Ojima H,Sakamoto M,Takayama T,Makuuchi M.Combined hepatocellular and cholangiocarcinoma:a clinicopathologic study of 26 resected cases.Jpn J Clin Oncol 2003; 33:283-287
  • 8[1]Libbrecht L,Roskams T.Hepatic progenitor cells in human liver diseases.Semin Cell Dev Biol 2002; 13:389-396
  • 9[2]Lowes KN,Brennan BA,Yeoh GC,Olynyk JK.Oval cell numbers in human chronic liver diseases are directly related to disease severity.Am J Pathol 1999; 154:537-541
  • 10[3]Libbrecht L,Desmet V,Van Damme B,Roskams T.Deepintralobular extension of human hepatic 'progenitor cells' correlates with parenchymal inflammation in chronic viral hepatitis:can 'progenitor cells' migrate? J Pathol 2000; 192:373-378

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  • 1Jerry W S,Woodring E W.Role of telomeres and telomerase in cancer[J].Seminars in cancer biology,2011,21(6):349-353.
  • 2Buseman C M,Woodring E W,Jerry W S.Is telomerase a viable target in cancer[J].Mutation research,2012,730:90-97.
  • 3Calvin B H.Telomerase and cancer therapeutics[J].Nature Reviews Cancer,2008,8:167-179.
  • 4Stewart H L,William G,Keysser C H,et al.Institute of laboratory animal resources:histological typing of liver tumors of the rat[J].J Natl Cancer Inst,1980,64:179-206.
  • 5Malenstein H V,Pelt J V,Verslype C.Molecular classification of hepatocellular carcinoma anno 2011[J].European journal of cancer,2011,47:1789-1797.
  • 6Michel M O,Woodring E W,Jerry W S.Targeting telomerase-expressing cancer cells[J].Journal of cellular and molecular medicine,2011,15(7):1433-1442.
  • 7Masayoshi M,Yuji K,Tetsuya A,et al.Prompt activation of telomerase by chemical carcinogens in rats deteced with a modified TRAPassay[J].Biochemical and biophysical research communications,1998,246:13-19.
  • 8Zhang H J,Yang J J,Tian J M,et al.Telomerase activity(TMA)in tumor and peritumoral tissues in a rat liver cancer model[J].Clini-cal and investigative medicine,2009,32(1):E8-12.
  • 9Stewart S A,Hahn W C,O’Connor B F,et al.Telomerase contributes to tumorigenesis by a telomere length-independent mechanism[J].PNAS,2002,99(20):12606-12611.
  • 10Cairney C J,Keith W N.Telomerase redefined:Integrated regulation of hTR and hTERT for telomere maintenance and telomerase ac-tivity[J].Biochimie,2008,90:13-23.

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实用医学杂志
2009年 第2期

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