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P糖蛋白与难治性癫痫的研究进展 被引量：1

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摘要 癫痫是神经系统的常见病、多发病，其患病率约1％-2％^[1]，国内有600万-700万的患者，其中约30％的患者因对抗癫痫药物耐药或其他原因而出现癫痫发作难以控制的现象，导致病程迁延并发展成为难治性癫痫（Intractable Epilepsy，IE）或顽固性癫痫（Refractory epilepsy，RE）[2]。现公认的难治性癫痫定义是：无中枢神经系统进行性疾病或占位性疾病，
作者 杨美兰 黄宗清
机构地区 深圳市第四人民医院神经内科
出处 《临床内科杂志》 CAS 2009年第1期70-71,共2页 Journal of Clinical Internal Medicine
关键词 P糖蛋白 癫痫
分类号 R742.1 [医药卫生—神经病学与精神病学]
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参考文献22

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  • 2Basic S,Hajnsek S,Bozina N,et al. The influence of C3435T polymorphism of ABCB1 gene on penetration of phenobarbital across the bloodbrain barrier in patients with generalized epilepsy. Seizure, 2008,17 : 524-530.
  • 3郭玉璞,王维治.神经病学.第2版.北京:人民卫生出版社,2006,1047-1058
  • 4Ohtsuki S, Takizawa T, Takanaga H, et al. Localization of organic anion transporting polypeptide 3 ( oatp3 ) in mouse brain parenchymal and capillary endothelial cells. J Neurochem ,2004,90:743-749.
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  • 6Lee G, Sehliehter L, Bendayan M, et al. Functional expression of P-glycoprotein in rat brain microglia. J Pharmacol Exp Ther, 2001,299: 204-212.
  • 7Bendayan R, Ronaldson PT, Gingras D, et al. In situ localization of P- glycoprotein ( ABCB1 ) in human and rat brain. J Histochem Cytochem, 2006,54:1159-1167.
  • 8Loscher W, Potschka H. Role of muhidrug transporters in pharmacoresistance to antiepileptic drugs. J Pharmacol Exp Ther,2002,301:7-14.
  • 9Marroni M ,Marchi N,Cucullo L,et al. Vascular and parenchymal mechanisms in multiple drug resistance:a lesson from human epilepsy. Curr Drug Targets, 2003,4 : 297 -304.
  • 10Loscher W. Drug transporters in the epileptic brain. Epilepsia,2007,48 : 8-13.

二级参考文献36

  • 1吴云娟,方晓玲.P-糖蛋白在药物脑部转运中作用的研究进展[J].中国临床药学杂志,2004,13(6):382-385. 被引量：5
  • 2王学嶂,沈鼎烈.卡马西平、苯妥英钠的耐受性研究[J].临床神经病学杂志,1993,6(4):226-228. 被引量：8
  • 3王学峰.丙戊酸镁的良性和不良耐受性[J].新药与临床,1993,12(5):289-290. 被引量：5
  • 4Sisodiya SM,Lin WR,Harding BN,et al.Drug resistance in epilepsy:expression of drug resistance proteins in common causes of refractory epilepsy.Brain,2002,125 (Pt 1):22-31.
  • 5Cole SP,Bhardwaj G,Gerlach JH,et al.Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.Science,1992,258:1650-1654.
  • 6Fromm MF. P-glycoprotein: a defense mechanism limiting oral bioavailability and CNS accumulation of drugs. Int J Clin Pharmacol Ther, 2000, 38: 69-74.
  • 7Tishler DM, Weinberg KT, Hinton DR, et al. MDR1 gene expression in brain of patients with medically intractable epilepsy.Epilepsia, 1995, 36 : 1-6.
  • 8Sisodiya SM,Lin WR, Harding BN, et al. Drug resistance in epilepsy: expression of drug resistance proteins in common cause of refractory epilepsy. Brain,2002,125:22-31.
  • 9Loscher W, Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J Phannacol Exp Ther,2002,301:7-14.
  • 10Leveille-Webster CR, Arias IM. The biology of the P-gIycoprotein. J Membr Biol, 1995, 143:89-102.

共引文献65

同被引文献4

  • 1金雪红,包仕尧.P-糖蛋白与血脑屏障[J].国际脑血管病杂志,2006,14(4):282-285. 被引量：14
  • 2Ohtsuka Y,Yoshinaga K. Refrctory childhood epilepsy and factors related to refractoriness[J]. Epilepsia, 2000,41 (suppl) : 14-17.
  • 3Loschez W. Drug transporters in the epileptic brain [J]. Epilepsia, 2007,48 (z1) : 8-13.
  • 4Bankstahl JP, Hoffmann K, Bethmann K ,et al. Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain [J]. Neuropharmacology , 2008 , 54 ( 6 ):1006-1016.

引证文献1

临床内科杂志
2009年 第1期

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