摘要
目的评价氟罗沙星注射液治疗细菌性感染的疗效及安全性。方法将124例患者随机分为氟罗沙星治疗组和氧氟沙星对照组各52例,开放组20例。治疗组和开放组用氟罗沙星0.2～0.4g静脉滴注,qd;对照组用氧氟沙星0.2～0.4g静脉滴注, bid;疗程均为7～14d。结果氟罗沙星注射液治疗总有效率为93.1%(67/72),与氧氟沙星相似;治疗组的有效率92.3%(48/52)与对照组的88.5%(46/52)相似(P>0.05)。不良反应发生率氟罗沙星组(6.9%)与氧氟沙星组(7.7%)相似(P>0.05)。结论氟罗沙星注射液治疗细菌性感染有效,安全。
Objective To evaluate the efficacy and safety of fleroxacin injection in the treatment of acute bacterial infections. Methods One hundred and four patients with respiratory and urinary tract infections were randomly divided into 2 groups, 52 patients were treated with fleroxacin, 52 patients were treated with ofloxacin. Another 20 patients treated with fleroxacin as open-label treated group. All were 0.2-0.4g iv drip, qd （fleroxacin） or bid （ofloxacin） for 7-14d. Results The overall clinical efficacy rates of fleroxacin was 93.1% （67/72）. The randomized comparison showed that the clinical efficacy rates of fleroxacin and ofloxacin were similar 92.3%（48/52） vs 88.5% （46/52）, P〉0.05. Conclusion Fleroxacin injection is an effective and safe antibacterial agent for the treatment of bacterial infections.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2009年第1期57-60,共4页
Chinese Journal of Antibiotics
关键词
氟罗沙星
氧氟沙星
细菌感染
Fleroxacin
Ofloxacin
Bacterial infections
