摘要
西罗莫司洗脱支架(SES)的应用使支架内再狭窄率降到了10%以下,但西罗莫司本身的药理特点使药物洗脱支架(DES)存在诸多缺陷,对西罗莫司的药理学研究将有利于SES的一步改进。本文根据大量的中外文献资料,着重介绍了西罗莫司在DES中的作用机制及其应用。
This article summarized the application of sirolimus (rapamycin) in drug-eluting stent(DES) and its working mechanism. A lot of clinical studies have shown sirolimus eluting stent (SES) reduced restenosis rate to less than 10% but sirolimus has also caused lots of problems in the DES. The pharmacological study of sirolimus would help further improvements in SES
出处
《世界临床药物》
CAS
2009年第1期52-55,共4页
World Clinical Drug
关键词
西罗莫司
药物洗脱支架
作用机制
不良反应
sirolimus
drug-eluting stent
working mechanism
adverse drug reaction