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西罗莫司在药物洗脱支架中的应用 被引量:1

Application of sirolimus in drug-eluting stent
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摘要 西罗莫司洗脱支架(SES)的应用使支架内再狭窄率降到了10%以下,但西罗莫司本身的药理特点使药物洗脱支架(DES)存在诸多缺陷,对西罗莫司的药理学研究将有利于SES的一步改进。本文根据大量的中外文献资料,着重介绍了西罗莫司在DES中的作用机制及其应用。 This article summarized the application of sirolimus (rapamycin) in drug-eluting stent(DES) and its working mechanism. A lot of clinical studies have shown sirolimus eluting stent (SES) reduced restenosis rate to less than 10% but sirolimus has also caused lots of problems in the DES. The pharmacological study of sirolimus would help further improvements in SES
出处 《世界临床药物》 CAS 2009年第1期52-55,共4页 World Clinical Drug
关键词 西罗莫司 药物洗脱支架 作用机制 不良反应 sirolimus drug-eluting stent working mechanism adverse drug reaction
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