摘要
目的系统评价全世界关于抗环瓜氨酸肽抗体诊断类风湿关节炎的文献质量,了解抗环瓜氨酸肽抗体诊断试验的方法学质量,并分析偏倚产生的来源和异质性产生的原因,为未来的临床研究提供参考依据。方法计算机检索PubMed(1966～2008.4)、EMbase(1974～2008.4)、Cochrane Library(2008年第3期)、中国生物医学文献数据库(1978～2008.4)、中文科技期刊全文数据库(1994～2008.4)和中国期刊全文数据库(1994～2008.4),手工检索相关期刊,全面收集抗环瓜氨酸肽抗体诊断类风湿关节炎的文献,应用QUADAS评价标准评价纳入文献的方法学质量。结果最终纳入195篇文献,其中英文69篇,中文126篇。纳入文献对疾病谱组成人群描述较好,部分文献参照偏倚、多重参照偏倚、金标准解读偏倚发生的可能性较小,但对待评价试验的实施报告较差,故疾病进展偏倚、试验解读偏倚、临床解读偏倚发生的可能性较大,有1篇研究出现了无法解释的中间试验结果,1篇研究无法确定部分实验结果的报道情况。英文文献在偏倚控制和报告质量上略好于中文文献。结论纳入文献的偏倚主要来源于待评价试验解读结果和临床解读结果时未实施盲法,整体文献报告质量较差。未来研究应严格按照诊断性试验报告标准(STARD)来报告。
Objective To evaluate the quality of diagnostic studies on detecting anti-cyclic citrullonated peptide antibody to diagnose rheumatoid arthritis. Methods We searched PubMed, EMbase, The Cochrane Library, and CBM to collect studies on using anti-cyclic citrullonated peptide antibody to diagnose rheumatoid arthritis. QUADAS items were used to evaluate the quality of included studies. Results A total of 195 studies were included. Sixty-nine were English studies and 126 were Chinese studies. All studies had good descriptions of the spectrum of patients and little potential for partial verification bias, differential verification bias, and incorporation bias. However, most studies were prone to disease progression bias, review bias, and clinical review bias, One study did not explain the intermediate test results, and another did not report part of the test results. The overall quality of English studies was better than that of Chinese studies. Conclusion The potential bias of the included studies mainly resulted from the absence of blinding when interpreting the test results. The reporting quality of the included studies was poor.
出处
《中国循证医学杂志》
CSCD
2009年第1期99-106,共8页
Chinese Journal of Evidence-based Medicine
基金
兰州大学学生创新创业行动计划
兰州大学循证医学中心本科教学创新项目资助(编号:2008-08)
关键词
抗环瓜氨酸肽抗体
类风湿性关节炎
诊断试验
质量评价
Anti-cyclic citrullonated peptide antibody
Rheumatoid arthritis
Diagnostic test
Quality assessment
