摘要
慢性炎症中持续的氧化应激导致DNA损伤并抑制损伤后修复，致使抑癌基因失活；微环境中炎症细胞以及炎症因子诱导多种细胞因子表达；炎症细胞和细胞因子及其下游产物通过抑制细胞凋亡，促进血管新生，诱导机体免疫耐受等多种方式促进肿瘤的发生、发展、转移。其中多个重要环节已得到详细阐述，并成为肿瘤治疗的靶点。本文就炎症与肿瘤的关系及其临床意义作一综述。
Sustained oxidative stress in the process of chronic inflammation leads to DNA damage and inhibition on its repair, resulting in inactivation of tumor suppressor genes. Inflammatory cells and inflammatory factors in the micro-environment can induce the expression of a variety of cytokines. These inflammatory cells, cytokines and their downstream products promote the occurrence, development and metastasis of cancer by various ways, such as inhibiting apoptosis, promoting angiogenesis and inducing immune tolerance. Several important links have been described in detail, and become the targets of cancer therapy. Therefore,the relationship between inflammation and cancer and its clinical significance are reviewed.
出处
《国际呼吸杂志》
2009年第2期104-108,共5页
International Journal of Respiration
