期刊文献+

CD62P与急性脑梗死的相关性 被引量:2

Relationship between CD62P and Acute Cerebral Infarction
下载PDF
导出
摘要 目的观察急性血栓性脑梗死(ATCI)和急性心源性脑栓塞(ACCE)患者CD62P的表达水平。方法利用流式细胞仪测定35例ATCI患者、30例ACCE患者和33例正常对照组血液样本CD62P的表达水平。结果与对照组相比,ATCI组和ACCE组CD62P均无升高(F=1.12,F=1.59,均P>0.05);ATCI组和ACCE组间CD62P表达水平也无显著性差异(F=1.12,P>0.05)。结论CD62P虽然是一种血小板活化标志物,但不论在急性血栓性脑梗死还急性心源性脑栓塞发病过程中,表达并无明显升高。 Objective To investigate the levels of CD62P expression on patients with acute tnrombotic cerebral infarction(AT-CI) or acute cardiogenic cerebral embolism (ACCE). Methods The levels of CD62P expression were detected with flow cytometry (FCM) in the blood of 35 patients with ATCI, 30 patients with ACCE, and 33 healthy controls. Results Comparing with the controls, the levels of CD62P expression on patients did not increase both in the ATCI group and the ACCE group. (F=1.12, F=1.59;P〉0.05). Furthermore, there wasn't significant difference in the expressions of CD62P between the ATCI group and the ACCE group. Conclusion The expressions of CD62P do not increase on the patients with ATCI and ACCE, although it is one of the markers of platelets activation.
作者 蒙绪卿
出处 《中国康复理论与实践》 CSCD 2009年第1期58-59,共2页 Chinese Journal of Rehabilitation Theory and Practice
基金 海南省自然科学基金项目(805104)
关键词 CD62P 急性血栓性脑梗死 急性心源性脑栓塞 流式细胞仪 CD62P acute thrombotic cerebral infarction acute cardiogenic cerebral embolism flow cytometry
  • 相关文献

参考文献19

  • 1包承鑫.血小板的生物化学性能和分子生物学:血小板功能[M].//张之南,杨天楹,郝玉书.血液病学(下册).北京:人民卫生出版社,2003:1527-1534,1530-1532.
  • 2Konstantopoulos K, Neelamegham S, Burns AR, et al. Venous levels of shear support neutrophil platelet adhesion and neutrophil aggregation in blood via P selectin and β2-intergrin[J]. Circulation, 1998,98:873-882.
  • 3Shattil SJ, Hoxie JA, Cunningham M, et al. Changes in the platelet membrane glycoprotein Ⅱb. Ⅲa. complex during platelet activation [J]. J Biol Chem, 1985, 260(20):11107-11114.
  • 4Zeller JA, Tschoepe D, Kessler C. Circulating platelets show in creased activation in patients with acute cerebral ischemia [J]. Thromb Haemost, 1999,81(3):373-377.
  • 5Dougherty JH Jr, Levy DE, Weksler BB. Platelet activation in acute cerebral ischaemia measurements function in cerebrovascular disease [J]. Lancet, 1977,(8016): 821-824.
  • 6Shah AB, Beamer N, Coull BM. Enhanced in vivo platelet activation in subtype of ischemic stroke[J]. Stroke,1985,16(4) :643-647.
  • 7Shattil SJ, Cunningham M, Hoxie JA. Detection of activated platelets in whole blood using activation-dependent monoclonal antibodies and flow cytometry[J]. Circulation, 1987,70 : 307-315.
  • 8Belniak Legiec E, Stelmasiak Z. Blood platelet activation markers in patients with acute cerebral infarction during the earliest stage of the disease evaluation using flow cytometry methods[J]. Neurol Neurochir Pol, 2000, 34(5) :853-864.
  • 9Satoh K, Yatomi Y, Ozaki Y. Detection method for platelet activation markers[J]. Rinsho Byori, 2002, 50(8):773-778.
  • 10Jy W, Horstman LI, Park H, et al. Platelet aggregates as markers of platelet activation: characterization of flow cytometric method suitable for clinical applications[J]. Am J Hematol,1998, 57(1):33-42.

二级参考文献4

  • 1Jerome SN, Dore M, Paulson JC, et al. P-selection and ICAM-1-depondent adherence reactions: role in the genesis of postischemic no-reflow.AM J Physiol, 1994,266:1316.
  • 2Soriano SG, Lipton SA, Wang YF, et al. Intercellular adhesion molecule-1-deficient mice are less suspectible to cerebral ischemia-repedusion injury. Ann Neurol, 1996,39;618.
  • 3Bitsch A, Klene W, Muttada L, et al. A longitudinal prospective study of soluble adhesion molecules in acute stroke.Stroke, 1998,29:2129.
  • 4Nurden AT, Bihour C, Macchi L, et al.Platelet activation in thrombotic disorders. Now Rev Fr Hemstol. 1993 : 35 : 67.

共引文献14

同被引文献30

引证文献2

二级引证文献10

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部