摘要
目的探讨肿瘤标志物癌胚抗原(CEA)联合恶性肿瘤特异性生长因子(TSGF)检测在胸腔积液诊断中的意义。方法采集有胸腔积液患者的血清和胸水样本各165例,其中恶性胸腔积液患者55例,良性胸腔积液患者110例,用化学发光法检测其血清和胸水癌胚抗原(CEA)、肿瘤特异性生长因子(TSGF)的含量。结果恶性胸水组血清CEA、TSGF的阳性率分别为58.8%,54.3%,胸水CEA、TSGF的阳性率分别为75.8%,70.7%;良性胸腔积液组CEA、TSGF血清及胸水的阳性率分别为0、18.4%和0、11.4%,差异有统计学意义(P〈0.01);两组含量的检测也得出相似的结果。联合检测血清CEA、TSGF诊断恶性胸腔积液的敏感度为85.7%,特异度为97.8%。结论肿瘤标志物CEA、TSGF联合检测,对胸腔积液的鉴别诊断有较好的临床价值。
Objective To study the clinical significance of tumor markers combined assay in the differential diagnosis of pleu.ral effusion. Methods 165 serum and hydrothorax samples were collected from 165 in-patients with pleural effusion. Among them,55 patients were suffered from malignant pleural effusion and 110 patients with benign p leural effusion. The concentration of CEA, and TSGF were determined by chemiluminescence assay. Results In ma- lignant pleural effusion group, the positive rates of serum CEA and TSGF were 58. 8% and 54. 3% respectively, the positive rates of hydrothorax CEA and TSGF were 75.8% ,70.7% respectively. Among them ,CEA and TSGF in malignant group were significantly higher than that in benign pleural effusion group( P 〈0.01 ). So as did of the concen- tration. The sensitivity of combined assay with serum TSGF in diagnosing malignant pleural effusion was 85.7% ,with the specificity of 97.8%. Conclusion Tumor markers of CEA and TSGF have high clinical values in the differential diagnosis of pleural effusion. The combined assay with TSGF is recommended.
出处
《中国基层医药》
CAS
2008年第11期1817-1818,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
胸腔积液
癌胚抗原
自身分泌活动因子
Pleural effusion
Careinoembryonie antigen
Autocrine motility factor