摘要
[目的]研究环维黄杨星D和羟丙基-β-环糊精的包合作用,寻找改善环维黄杨星D制剂性能的方法。[方法]采用相溶解度法研究环维黄杨星D和羟丙基-β-环糊精在水溶液中的包合作用;溶液搅拌法制备包合物;差示扫描量热法验证包合物的形成。比较了环维黄杨星D和包合物体外溶出度。[结果]在水溶液中环维黄杨星D和羟丙基-β-环糊精能够形成摩尔比为1∶1的包合物,包合反应是可以自发进行的放热过程。包合后环维黄杨星D10 min内的溶出度由14.7%提高到86.4%。[结论]环糊精包合技术显著提高了环维黄杨星D的溶解度和溶出度。
[ Objective ] The inclusion complex of cyclovirobuxine D and hydroxypropyl-β-cyclodextrin was investigated to improve the performance of the cyclovirobuxine D preparation. [ Method] In aqueous solution, the inclusion complex of cyclovirobuxine D/hydroxypropyl-β-cyclodextrin was studied by phase solubility. The inclusion complex was prepared by solution-agitation technology and was confirmed by DSC. At the same time, the dissolution of cyclovirobuxine D and inclusion complex were measured. [ Result] A molar ratio inclusion complex （ 1：1 ） of cyclovirobuxine D with hydroxypmpyl-β-eyclodextrin in aqueous solution was spontaneously thermopositive process. Inclusion with hydroxypropyl-β-cyclodextrin, the dissolution rate of cyclovimbuxine D in 10 minutes increased from 14.7% to 86.4%. [ Conclusion] The solubility and dissolution of cyclovimbuxine D were improved remarkably with hydmxypmpyl-β-cyclodextrin.
出处
《安徽农业科学》
CAS
北大核心
2008年第35期15302-15303,15305,共3页
Journal of Anhui Agricultural Sciences
基金
江苏省高校自然科学研究计划(06KJD350149)
