摘要
目的探讨人肝细胞性肝癌（HCC）细胞株和组织中胃泌素受体（GR）的表达和临床病理学意义。方法免疫组织化学染色方法检测四种人HCC细胞株和25例人HCC组织中GR的表达。结果显示在较高一抗浓度下，三种人HCC细胞株可见GR阳性表达，表达强弱为SMMC-7721〉HepG2〉QGY-7701。在人HCC组织中GR的阳性表达率为56％（14／25）。但GR的表达与病人性别、年龄、临床分期、有否乙肝后肝硬化、肿瘤大小均无明显相关性。有脉管癌栓组与无脉管癌栓组显示出GR表达差异有统计学意义。结论在肝细胞肝癌中存有胃泌素受体表达。是否具有内分泌治疗意义尚须进一步研究。
Objective To study the expression of gastrin receptor in 4 HCC cell lines and tissues and their relation to clinicopathological features. Methods Immunohistochemical staining of GR was performed for the 4 HCC cell lines and the paraffin sections of 25 HCC cases. The relationship be tween the GR expression in HCC sections and the clinicopathological parameters were analyzed. Resuits Positive staining for GR in the 3 HCC SMMC-7721〉HepG2〉QGY 7701 cell lines and HCC tissues was observed. The expression rate of gastrin receptor was 56% （14/25）. However, there was no association between expression of GR and clinicopathological features such as age, gender and clinical stage etc except for tumor thrombosis. Conclusion GR exists in the HCC. Futher study is needed to identify whether GR is a applicable target for endocrine therapy in HCC.
出处
《中华肝胆外科杂志》
CAS
CSCD
2008年第12期881-883,共3页
Chinese Journal of Hepatobiliary Surgery
关键词
癌
肝细胞
胃泌素受体
免疫组织化学
Carcinoma hepatocellular
Gastrin/CCK2 receptor
Immunohistochemistry
