摘要
目的:应用多层螺旋CT探讨急性胰腺炎(acute pancreatitis,AP)患者胰腺CT灌注的变化以及CT灌注参数与急性胰腺炎临床常用病情指标的关系,以探讨CT灌注成像在急性胰腺炎中的临床应用价值.方法:2006-08/2008-01急性胰腺炎患者82例,入院后2-3d采用德国Siemenssomatom Sensation64层螺旋CT进行动态增强扫描,其中5例因患者移动等致胰腺CT灌注成像失败.30例对照组,其中3例健康志愿者,27例因其他疾病行腹部CT检查患者.利用螺旋CT自带软件PCT进行处理得到灌注参数:BF(血流量)、BV(血容量)、TTP(峰值时间)、PS(表面通透性)等.结果:急性胰腺炎组BF、BV较正常对照组相比下降明显(110.57±60.04vs133.55±25.70,156.68±65.11vs193.78±27.01,均P<0.05),TTP、PS变化无统计学意义.重型急性胰腺炎与轻型急性胰腺炎相比,住院时间延长(11.51±8.46dvs20.91±8.40d,P<0.05),而腹痛缓解时间离散度大,虽有延长趋势,但无统计学意义.急性胰腺炎CT灌注参数BF、BV与腹痛缓解时间、住院总时间、局部并发症间存在相关关系(P<0.05).结论:急性胰腺炎患者胰腺血流灌注降低,灌注参数BV、BF与AP临床常用病情指标存在相关关系,CT灌注成像在AP病情评估中具有临床应用价值.
AIM： To examine the blood perfusion characteristics of acute pancreatitis （AP） using multisection dynamic CT, and to detect relationship between perfusion parameterss and severity indicators in acute pancreatitis.
METHODS： A total of 112 cases （30 cases with normal pancreas and 82 AP patients） were examined for pancreatic perfusion from August in 2006 to January in 2008. These datas were processed on a SIEMENS workstation using PCT software package, and the mean BF, BV, TTP, PS were measured and statistically analyzed in 112 patients.
RESULTS： BF and BV had a significant decrease between acute pancreatitis group and normal control group （110.57 ± 60.04 vs 133.55 ± 25.70, 156.68 ± 65.11 vs 193.78 ± 27.01, both P 〈 0.05）, but TTP and PS showed no significant change. Compared with mild acute pancreatitis, severe pamcreatitis showed longer hospital stay （11.51 ± 8.46 d vs 20.91 ± 8.40 d, P 〈 0.05）, longer but not significant time for easing abdominal pain. Acute pancreatitis CT perfusion parameters BF, BV were related to pain of time, total time of hospitalization, and local complications （P 〈 0.05）.
CONCLUSION： Multisection Spiral CT （MSCT） perfusion imaging may reflect the features of pancreatic perfusion in acute pancreatitis. The BF and BV are markedly decreased in AP. The BF and BV are predictors for assessing acute pancreatitis patients.
出处
《世界华人消化杂志》
CAS
北大核心
2008年第35期3958-3962,共5页
World Chinese Journal of Digestology
