摘要
目的：比较冠心病、高血压病、高血压病伴冠心病患者胰岛素抵抗及卡托普利（ｃａｐｔｏｐｒｉｌ）对其胰岛素抵抗的影响。方法：２０例正常对照组及２０例冠心病组、２０例高血压病组、１８例高血压病伴冠心病组患者均行口服葡萄糖耐量试验，测血糖、血胰岛素，之后除正常对照组外，其余３组服卡托普利１２．５ｍｇ／ｄ，共４周，于第４周重复葡萄糖耐量试验，通过血糖、血胰岛素来计算空腹血胰岛素与血糖比值（Ｉ／Ｇ），糖耐量、胰岛素释放曲线下面积多组均数间的两两比较用方差分析和ｑ检验，同组治疗前后配对资料用ｔ检验。结果：冠心病组、高血压病组、高血压病伴冠心病组患者血糖、血胰岛素、Ｉ／Ｇ均高于正常对照组；高血压病组Ｉ／Ｇ大于冠心病组（Ｐ＜０．０５）；高血压病伴冠心病组糖负荷后２小时血胰岛素下降慢，其值高于其它两组（Ｐ＜０．０５）；卡托普利治疗后３组患者血糖、血胰岛素、Ｉ／Ｇ、糖耐量、胰岛素释放曲线下面积均较治疗前下降。结论：冠心病组、高血压病组、高血压病伴冠心病组患者均存在胰岛素抵抗，高血压病伴冠心病组患者高胰岛素血症更明显，持续时间更长。卡托普利能改善以上３组患者的胰岛素抵抗。
? Objective:To compare the differences of insulin resistance (ISR) in patients with coronary heart disease(CHD),essential hypertension(EH),and EH complicated with CHD(EHC) and the effects of captopril on ISR in those patients. Methods:Oral glucose tolerance test and insulin release test were studied in control group(n=20) and in patient groups with CHD (n=20),EH (n=20) and EHC (n=18) before and after taking captopril(125 mg/d)for 4 weeks. Results:The blood glucose level,blood insulin level,fast blood insulin/glucose ratio in CHD,EH and EHC were higher than those in the control group. The I/G ratio in EH group was higher than in CHD group(p<005).During the insulin release test at 2 h,serum insulin was higher in EHC than in EH and CHD (p<005).In the 4th week after taking captopril,the blood glucose,blood insulin,fast insulin/glucose ratio,the area under glucose tolerance curve and area under insulin release curve in CHD,EH and EHC were reduced. Conclusions:ISR is present in patients with CHD,EH and EHC.Hyperinsulinemia in EHC is the most obvious and lasts longer.Captopril can improve ISR in all patients studied.
出处
《中国循环杂志》
CSCD
北大核心
1998年第1期15-16,共2页
Chinese Circulation Journal
关键词
卡托普利
冠心病
高血压
胰岛素抵抗
药物疗法
Captopril
Coronary heart disease
Essential hypertension
Insulin resistance
