摘要
目的：探讨高胰岛素血症（ＨＩＳ）与盐敏感性高血压病肾脏排钠障碍间的关系。方法：根据盐敏感性（盐负荷试验Ｓｕｌｉｖａｎ标准），将５３例高血压病患者分为２组：盐敏感型（ＳＳ）组２２例、盐不敏感型（ＳＲ）组３１例。测定患者在盐负荷试验中血糖和血胰岛素浓度变化，计算胰岛素抵抗。结果：ＳＳ组与ＳＲ组相比较，基础状态、盐负荷和服呋喃苯胺酸（速尿）后各时点血糖及血胰岛素变化明显（血糖：５．１２±１．２５、５．９７±１．５９、５．２１±１．２８ｍｍｏｌ／Ｌ比４．９６±１．１４、５．４８±１．３８、５．０７±１．２３ｍｍｏｌ／Ｌ，Ｐ＞０．０５；血胰岛素：１２．４６±４．１４、３１．６８±１２．２１、１４．３５±４．４５ｍＵ／Ｌ比１０．１５±３．６２、２２．１４±８．６４、１０．８９±３．９１ｍＵ／Ｌ，Ｐ＜０．０１），ＳＳ组中胰岛素抵抗发生率显著高于ＳＲ组（６３．６％比３２．３％，Ｐ＜０．０５）。结论：ＳＳ高血压病肾脏排钠障碍与高胰岛素血症有关。
? Objective:To study the relationship between hyperinsulinemia and impaired renal sodium excretion in the saltsensitive(SS) hypertension. Methods:The saline loading test was performed on 53 patients with essential hypertension.According to Sullivans standard,22 of the 53 patients were SS,31 were saltresistant(SR).The serum glucose(SG)and insulin(IS)concentration were measured during salt loading test. Results:The great changes of SG and IS were shown in SS group as compared with SR group before and after salt loading and after the furosemide sodiumvolume depletion(SG:512±125、597±159、521±128 mmol/L、vs.496±114、548±138、507±123 mmol/L,p>005;IS:1246±414、3168±1221、1435±445 mU/L vs.1015±362、2214±864、1089±391 mU/L,p<001).The prevalence rate of insuline resistance in SS group was higher than that in SR(636% vs.323%,p<005). Conclusion:The results suggest that there is a close relationship between hyperinsulinemia and impaired renal sodium excretion in the SS hypertension.
出处
《中国循环杂志》
CSCD
北大核心
1998年第1期17-19,共3页
Chinese Circulation Journal
基金
江苏省卫生厅
徐州市医药卫生科研基金
关键词
高血压
盐敏感性
肾脏排钠
高胰岛素血症
Essential hypertension
Saltsensitive
Renal sodium excretion
Hyperinsulinemia
