摘要
肝纤维化的本质是肝脏内结缔组织的增生大于降解，从而引起细胞外基质过度沉积。肝星形细胞（HSCs）在这一过程中起到至关重要的作用，其活化和凋亡与肝纤维化形成及逆转密切相关。因此，寻找抑制HSCs活化、促进HSCs凋亡的途径是防治肝纤维化的重要策略。近年来对HSCs活化和凋亡的研究己取得了一些新的进展。本文简要综述了HSCs及相关细胞因子干扰素、肿瘤坏死因子在肝纤维化形成过程中的生物学作用。
The essence of liver fibrosis is the hyperplasia of connective tissue faster than its degradation in liver,leading to the excessive accumulation of extracellular matrix. Hepatic stellate cells （HSCs） play an important role in the progression of liver fibrosis. There is an intimate relationship between the activation, ap- optosis of HSCs and the formation,reversion in liver fibrosis. Some new progress in the activation and apopto- sis of HSCs has been made in recent years. This article summarized the biologic activity of HSCs, as well as IFN and TNF in the progression of liver fibrosis.
出处
《医学综述》
2009年第3期392-394,共3页
Medical Recapitulate
关键词
肝纤维化
肝星形细胞
干扰素
肿瘤坏死因子
Liver fibrosis
Hepatic stellate cells
Interferon
Tumor necrosis factor
