期刊文献+

新型调脂药——多廿烷醇临床应用评价 被引量:11

Clinical assessment of policosanol-a new vegetal drug for regulating serum lipid
原文传递
导出
摘要 多廿烷醇是一种新型调脂药,可以抑制胆固醇合成及提高低密度脂蛋白的血液清除率。降脂效果与他汀类药物相似,对于特殊人群如老年人、肝病患者,其临床有效性、安全性和耐受性已经为多个临床研究证实。与他汀类、贝特类药物联合应用安全性良好。可作为高胆固醇血症、高低密度脂蛋白胆固醇血症或低高密度脂蛋白胆固醇血症患者一级预防治疗用药和不能耐受其他降脂药物的二级预防治疗用药。多廿烷醇对动脉粥样硬化危险因素的长期临床作用还需要进一步研究。 Sumrnary:Policosanol is a new drug for regulating lipid, which can inhibit eholesterin synthesis and increase blood clearance of low-density lipoprotein (LDL). It has similar effect as statins and its clinical efficiency, safety and tolerance for special people such as the old and those with hepatopath have been confirmed by many clinical studies. Polieosanol combined with statins or fibrates is also safe,which can be used as primary prevention for the patients with hypercholesterinemia, high low-density lipoprotein-cholesterolor low high-density lipoprotein-cholesterol and as secondary prevention for the patients who could not tolerate other lipid-regulating drugs. The longterm clinical effect of Policosanol on the risk factors of atherosclerosis need further researches.
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2009年第1期17-19,共3页 Chinese Journal of Practical Internal Medicine
关键词 降血脂药 高脂血症 多廿烷醇 antilipemic agents hyperlipidemia policosanol
  • 相关文献

参考文献7

  • 1Singh DK, Li L, Porter TD. Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase [ J ]. J Pharmacol Exp Ther,2006,318 ( 3 ) : 1020 - 1026.
  • 2王云,柯元南,王嘉莉,焦媛,赵秀丽,孙宁玲,杨新春,孙瑞华.多廿烷醇与普伐他汀治疗高脂血症的疗效和安全性[J].中国新药与临床杂志,2008,27(2):124-128. 被引量:12
  • 3Fernamdez S,Mas R, Gamez R,et al. A pharmacological surveillance study of the tolerability of policosanol in the elderly population [ J ]. Am J Geriatr Pharmacother,2004,2 ( 4 ) :219 - 229.
  • 4Castano G, Fernandez L, Mas R, et al. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus [ J ]. Chn Drug Investig,2003,23 (10) :639 -650.
  • 5Dulin MF, Hatcher LF, Sasser HC, et al. Policosanol is ineffective in the treatment of hypereholesterolemia: a randomized controlled trial[J]. Am J Clin Nutr,2006,84(6) :1543 - 1548.
  • 6Berthold HK, Unverdorben S, Degenhardt R, et al. Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial [ J ]. JAMA ,2006,295 ( 19 ) :2262 - 2269.
  • 7Cubeddu LX, Cubeddu R J, Heimowitz T, et al. Comparative lipidlowering effects of policosanol and atorvastatin : a randomized narallel, double-blind, placebo-controlled trial [ J ]. Am Heart J, 2006, 152(5 ) :982, e1- e5.

二级参考文献7

  • 1MAS R, CASTANO G, FEMANDEZ J, et al. Long-term effects of policosanol on obese patients with type Ⅱ hypercholesterolemia [J]. Asia Pac J Clin Nutr, 2004, 13 Suppl: S102-S108.
  • 2MENENDEZ R, MARRERO D, MAS R, et al. In vitro and in vivo study of octacosanol metabolism[J]. Arch Med Res, 2005, 36(2):113-119.
  • 3CASTANO G, MAS R, FERNANDEZ JC, et al. Effects of policosanol on older patients with hypertension and type H hypercholesterolaemia[J]. Drugs R D, 2002; 3(3):159-172.
  • 4CASTANO G, MAS R, ARRUZAZABALA ML, et al. Effects of policosanol and pravastatin on lipid profile, platelet aggregation and endothelemia in older hypercholesterolemic patients[J]. Int J Clin Pharmacol Res, 1999, 19(4): 105-116.
  • 5MENENDEZ R, AMOR AM, RODEIRO I, et al. Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts[J]. Arch Med Res, 2001,32(1):8-12.
  • 6MENENDEZ R, MAS R, AMOR AM, et al. Effects of policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro [J]. Br J Clin Pharmaco, 2000, 50(3):255-262.
  • 7CASTANO G, MAS R, FERNANDEZ L, et al. Comparison of the efficacy and tolerability of policosanol with atorvastatin in elderly patients with type Ⅱ hypercholesterolaemia [J]. Drugs Aging, 2003, 20(2): 153-163.

共引文献11

同被引文献81

引证文献11

二级引证文献38

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部