摘要
为了克服传统的X射线乳腺成像术在灵敏度、特异性、安全性和舒适性等方面存在的重大缺陷,提出了一种面向乳腺成像的时域扩散光学层析(diffuse optical tomography,DOT)图像重建技术.该技术以拉普拉斯变换时域扩散方程的有限元(finite element method,FEM)数值解作为正向模型,采用基于牛顿-拉夫逊迭代格式的逆模型框架.通过对锥形压缩乳房光学层析模式的模拟实验研究表明,该方法可有效重构出乳腺肿瘤组织的吸收系数μa和约化散射系数μs′的层析图像,且成像目标的空间位置准确,具有较高的图像质量.
To overcome the deficiencies of conventional X-ray mammography in sensitivity, specificity, security and comfortableness, an image reconstruction technique of time-domain diffuse optical tomography ( DOT ) for the optical mammography was presented. The technique used the finite element method ( FEM ) solution to the Laplace-transformed coupled diffusion equations as the forward model, and developed the inverse model based on a Newton-Raphson scheme. The simulation experiments of breast DOT in conical compression modality indicate that: the proposed methodology can effectively reconstruct the absorption and scattering coefficient distributions of the breast tissue; the spatial location of tumor tissue can be exactly reconstructed with high quality of image.
出处
《纳米技术与精密工程》
EI
CAS
CSCD
2009年第1期60-64,共5页
Nanotechnology and Precision Engineering
基金
国家重点研究发展计划(973)项目(2006CB705700)
国家自然科学基金资助项目(60578008
60678049)
天津市自然科学基金资助项目(07JCYBJC06600)
关键词
乳腺癌早期检测
时域扩散光学层析
有限元法
图像重建技术
breast cancer earlier examination
time-domain diffuse optical tomography (DOT)
finite element method ( FEM )
image reconstruction technique