摘要
目的分析141株临床分离的鲍氏不动杆菌对15种常用抗菌药物的耐药性,为临床合理用药提供依据。方法琼脂稀释法测定鲍氏不动杆菌对美罗培南、亚胺培南、哌拉西林、哌拉西林/他唑巴坦等15种抗菌药物的最低抑菌浓度(MIC)。结果鲍氏不动杆菌对亚胺培南的耐药率最低(6.4%)、其次为美罗培南(20.5%)和头孢哌酮/舒巴坦(29.7%),对四环素的耐药率最高(81.5%);其余抗菌药物耐药率均约在50.0%。结论鲍氏不动杆菌对亚胺培南、美罗培南、头孢哌酮/舒巴坦较敏感,对其他抗菌药物耐药情况严重,临床应加强检测和监测。
OBJECTIVE To analyze the drug resistance of 141 clinical strains of Acinetobacterbaumannii to 15 kinds of antimicrobial agents for the rational application of antimicrobial agents. METHODS All 141 strains of A. baumannii isolates were tested for minimal inhibitory concentration （MIC） to 15 kinds of antimicrobial agents included meropenem, imipenem, piperacillin, and so on using agar dilution method. RESULTS The lowest resistance rate of A. baumannii to the antimicrobial agents was to imipenem （22.7%）, then was to meropenem and cefoperazone/ sulbactam. The highest resistance rate was tetracycline （81. 5%）. The resistance rate to other antimicrobial agents was to about or more than 50%. CONCLUSIONS Most of A. baumannii isolates are susceptible to meropenem, imipenem, and cefoperazone/sulbactam and resistant to other antimicrobial agents, therefore, we should enhance to this kind of isolates detection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第2期223-224,共2页
Chinese Journal of Nosocomiology
基金
安徽省自然科学基金(050430804)
安徽省优秀青年科技基金(08040106815)
关键词
鲍氏不动杆菌
抗菌药物
耐药性
Acinetobacterbaumannii
Antimicrobial agents
Resistance
