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子宫内膜癌中ERK1/2信号转导通路与雌、孕激素受体的相关性 被引量：20

Relationship between ERK1/2 signal transduction pathway and estrogen receptor and progesterone receptor in endometrial carcinoma
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摘要 目的检测丝裂原活化蛋白激酶(MAPK)信号通路中细胞外信号调控激酶1/2(ERK1/2)在子宫内膜癌中的表达,探讨其与雌激素受体(ER)和孕激素受体(PR)表达间的相关性。方法用免疫组化方法(SP法)检测30例子宫内膜癌石蜡标本中ERK1/2以及ER和PR的表达;同法检测20例正常子宫内膜、13例增生过长子宫内膜石蜡标本中ERK1/2的表达;对标本的染色情况做半定量分析。结果ERK1/2在正常子宫内膜、增生过长子宫内膜和子宫内膜癌中的表达水平比较,差异无统计学意义(P>0.05)。磷酸化的ERK1/2(p-ERK1/2)在ER阳性与ER阴性子宫内膜癌中的高表达率比较(76.5%vs30.8%),差异有统计学意义(P<0.05);且p-ERK1/2的高表达率与ER的表达水平呈正相关(r=0.457,P<0.05);p-ERK1/2的高表达率与PR的表达水平无相关性(P>0.05)。结论ERK1/2信号转导通路与子宫内膜恶变过程无相关性,其活化与ER表达水平呈正相关。ER可能通过ERK1/2信号通路发挥其在子宫内膜癌中的调控作用。 Objective To detect the expression of extracellular signal-regulated kinase 1/2 （ERK1/2） in endometrial carcinoma, and investigate its relationship with the expression of estrogen receptor （ER） and progesterone receptor （PR） . Methods The expression of ERK1/2, ER and PR in 30 endometrial carcinoma specimens was detected by immunohistochemical method （SP method）. With the same method, the expression of ERK1/2 was detected in 20 normal endometria specimens and 13 hyperplastic endometria specimens. Semi-quantitative analysis of specimen staining was conducted. Results There was no significant difference in the expression of ERK1/2 among normal endometria, hyperplastic endometria, and endometrial carcinoma （ P 〉 0.05）. There were significant differences in the expression of phosphorylated ERK1/2 （p-ERK1/2） between ER positive endometrial carcinoma （76. 5% ） and ER negative one （30.8%） （P 〈 0.05）. The higher expression of p-ERK1/2 was closely related to ER expression （r = 0. 457, P 〈 0.05） , while not related to the expression of PR （ P 〉 0. 05 ）. Conclusion The progression from normal to malignant endometrium is not related to the activation of ERK1/2. The level of activated ERK1/2 is positively correlated with the expression of ER in endometrial carcinoma. ER may regulate the growth of endometrial carcinoma cells via ERK1/2 signal transduction pathway.
作者 鲍伟 蔡斌 杨懿霞 刘雪莲 万小平
机构地区 上海交通大学第一人民医院妇产科
出处 《上海交通大学学报（医学版）》 CAS CSCD 北大核心 2009年第1期5-8,共4页 Journal of Shanghai Jiao tong University:Medical Science
基金 国家自然科学基金(30672236) 上海市自然科学基金(06ZR14053)~~
关键词 子宫内膜癌 细胞外信号调控激酶1/2 雌激素受体 孕激素受体 endometrial carcinoma extracellular signal-regulated kinase 1/2 estrogen receptor progesterone receptor
分类号 R737.33 [医药卫生—肿瘤]
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上海交通大学学报（医学版）
2009年 第1期

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