摘要
目的探讨川崎病(KD)并葡萄糖-6-磷酸脱氢酶(G-6-PD)缺陷症患儿的治疗和转归。方法KD患儿624例,其中32例并G-6-PD缺陷症。624例KD患儿均予同等剂量的静脉用丙种球蛋白(IVIG)治疗(2g/kg),32例并G-6-PD缺陷症患儿采用双嘧达莫代替阿司匹林(ASA)在非急性期治疗。行心脏超声检查追踪治疗后冠状动脉损害转归。比较32例KD并G-6-PD缺陷症患儿与从所有KD患儿中随机选择的356例KD患儿的转归。应用SPSS10.0软件进行统计学分析。结果32例KD并G-6-PD缺陷症的患儿冠状动脉瘤发生率为12.5%(4例),与总体中冠状动脉瘤发生率(13.5%)比较差异无统计学意义。32例并G-6-PD缺陷症的KD冠状动脉损害者经治疗6～12个月后,冠状动脉恢复至正常者占62.5%,好转者占21.9%,无好转者占15.6%,其转归与总体KD患者的冠状动脉转归比较无显著性差异(Z=-1.604P=1.09)。结论双嘧达莫具有保护冠状动脉和防治血小板聚集的作用,KD并G-6-PD缺陷症的患儿采用双嘧达莫代替ASA与IVIG联合治疗是可行的。
Objective To evaluate the therapy and turnover of Kawasaki disease（KD） with glucose -6 -phosphate dehydrogenase （G - 6 - PD） deficiency. Methods Six hundred and twenty - four patients with KD were selected including 32 patients who had G - 6 - PD defec- ted. The same dose intravenous immunoglobulin （IVIG） was used in all 624 patients （2 g/kg）, but used Dipyridamole in 32 patients had G - 6 - PD deficiency which replaced the role of acetylsalicylic acid（ASA） after acute period. The coronary artery of these patients were checked and followed - up through echocardiograph. The turnover of 32 patients with G - 6 - PD deficiency and 356 case selected randomly from all the KD patients were compared. SPSS 10.0 software was used to analyze the data. Results In 32 cases of KD with G - 6 - PD deficiency ,4 chil- dren had coronary aneurysm（ 12.5 % ）. After 6 -12 months follow -up, the coronary lesions were recovered in 62.5% children, improved in 21.9% children and not improved in 15.6% childern,which were not significantly different from all the KD patients （Z = - 1. 604 P = 1.09 ）. Conclusions IVIG and Dipyridamole are feasible in treating KD with G - 6 - PD deficiency.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2009年第1期26-27,47,共3页
Journal of Applied Clinical Pediatrics
