摘要
目的研究虚证状态下乌头属药用植物炮制减毒对药效的影响。方法采用喂食肥甘生冷食物造成脾失健运的虚证模型。观察虚证状态下药物炮制减毒后对药效的影响。结果在给予相同剂量的前提下,药物经过炮制后毒性降低明显,与炮制后化学成分变化密切相关,而在毒性降低的同时,药效没有降低。结论脾虚状态下乌头属植物经过炮制后镇痛作用没有降低,有的药品经过炮制后镇痛作用略有增强。
Objective To research the effects of different processed Aconitum in the Asthenia Syndrome Model. Methods Asthenia syndrome model was established through feeding fat and cabbage to make dys - splenism. The changes of analgesic effects of different processed Aconitum and raw Aconitum in asthenia syndrome model were observed. Results With the same dosage, the toxic effect has reduced significantly through processing, but the pharmacodynamic action didnt decrease. The reason may be related with the changes of chemical constitution after the processing of Aconitum. Conclusion Analgesic effect of the processed Aconirum doesnt decrease, but the toxicity decreases in Asthenia syndrome model.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2009年第1期14-15,共2页
Lishizhen Medicine and Materia Medica Research
基金
国家"973"计划项目(No.2006CB504706)
关键词
脾虚模型
乌头
炮制
急性毒性
镇痛
Asthenia syndrome model
Aconitum
Processing
Acute toxicity
Analgesic Effect
